Molecular Epidemiology of Dengue in Panama: 25 Years of Circulation

Yamilka Díaz, María Chen-Germán, Evelia Quiroz, Jean Paul Carrera, Julio Cisneros, Brechla Moreno, Lizbeth Cerezo, Alex O. Martinez-Torres, Lourdes Moreno, Itza Barahona de Mosca, Blas Armién, Rubing Chen, Nikos Vasilakis, Sandra López-Vergès

Research output: Contribution to journalArticle

Abstract

Dengue virus (DENV) is the most prevalent arbovirus in terms of human public health importance globally. In addition to DENV epidemiological surveillance, genomic surveillance may help investigators understand the epidemiological dynamics, geographic distribution, and temporal patterns of DENV circulation. Herein, we aimed to reconstruct the molecular epidemiology and phylogeny of DENV in Panama to connect the epidemiological history of DENV dispersal and circulation in Latin America. We retrospectively analyzed the epidemiological data obtained during 25 years of DENV surveillance in Panama. DENV was reintroduced in Panama in 1993 after a 35 year absence of autochthonous transmission. The increase in the number of total dengue cases has been accompanied by an increase in severe and fatal cases, with the highest case fatality rate recorded in 2011. All four serotypes were detected in Panama, which is characterized by serotype replacement and/or co-circulation of multiple serotypes. Phylogenetic analysis of datasets collected from envelope (E) gene sequences obtained from viruses isolated from human sera demonstrated that circulating viruses were highly diverse and clustered in distinct clades, with co-circulation of clades from the same genotype. Our analyses also suggest that Panamanian strains were related to viruses from different regions of the Americas, suggesting a continuous exchange of viruses within the Americas.

Original languageEnglish (US)
JournalViruses
Volume11
Issue number8
DOIs
StatePublished - Aug 20 2019

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Panama
Dengue Virus
Molecular Epidemiology
Dengue
Viruses
Arboviruses
Infectious Disease Transmission
Latin America
Phylogeny
Public Health
History
Genotype
Research Personnel
Mortality
Serum

Keywords

  • arbovirus
  • Dengue virus
  • Flavivirus
  • molecular epidemiology
  • outbreak
  • Panama
  • the Americas

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Díaz, Y., Chen-Germán, M., Quiroz, E., Carrera, J. P., Cisneros, J., Moreno, B., ... López-Vergès, S. (2019). Molecular Epidemiology of Dengue in Panama: 25 Years of Circulation. Viruses, 11(8). https://doi.org/10.3390/v11080764

Molecular Epidemiology of Dengue in Panama : 25 Years of Circulation. / Díaz, Yamilka; Chen-Germán, María; Quiroz, Evelia; Carrera, Jean Paul; Cisneros, Julio; Moreno, Brechla; Cerezo, Lizbeth; Martinez-Torres, Alex O.; Moreno, Lourdes; Barahona de Mosca, Itza; Armién, Blas; Chen, Rubing; Vasilakis, Nikos; López-Vergès, Sandra.

In: Viruses, Vol. 11, No. 8, 20.08.2019.

Research output: Contribution to journalArticle

Díaz, Y, Chen-Germán, M, Quiroz, E, Carrera, JP, Cisneros, J, Moreno, B, Cerezo, L, Martinez-Torres, AO, Moreno, L, Barahona de Mosca, I, Armién, B, Chen, R, Vasilakis, N & López-Vergès, S 2019, 'Molecular Epidemiology of Dengue in Panama: 25 Years of Circulation', Viruses, vol. 11, no. 8. https://doi.org/10.3390/v11080764
Díaz Y, Chen-Germán M, Quiroz E, Carrera JP, Cisneros J, Moreno B et al. Molecular Epidemiology of Dengue in Panama: 25 Years of Circulation. Viruses. 2019 Aug 20;11(8). https://doi.org/10.3390/v11080764
Díaz, Yamilka ; Chen-Germán, María ; Quiroz, Evelia ; Carrera, Jean Paul ; Cisneros, Julio ; Moreno, Brechla ; Cerezo, Lizbeth ; Martinez-Torres, Alex O. ; Moreno, Lourdes ; Barahona de Mosca, Itza ; Armién, Blas ; Chen, Rubing ; Vasilakis, Nikos ; López-Vergès, Sandra. / Molecular Epidemiology of Dengue in Panama : 25 Years of Circulation. In: Viruses. 2019 ; Vol. 11, No. 8.
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