Molecular evolution and phylogeny of dengue-4 viruses

Robert S. Lanciotti, Duane J. Gubler, Dennis W. Trent

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

Nucleotide sequences of the envelope protein genes of 19 geographically and temporally distinct dengue (DEN)-4 viruses were determined. Nucleic acid sequence comparison revealed that the identity among the DEN-4 viruses was greater than 92%. Similarity among deduced amino acids was between 96 and 100%; in most cases identical amino acid substitutions occurred among viruses from similar geographical regions. Alignment of nucleic acid sequences followed by parsimony analysis generated phylogenetic trees, which indicated that geographically independent evolution of DEN-4 viruses had occurred. DEN-4 viruses were separated into two genetically distinct subtypes (genotypes). Genotype-1 contains viruses from the Philippines, Thailand and Sri Lanka; genotype-2 consists of viruses from Indonesia, Tahiti, the Caribbean Islands (Puerto Rico, Dominica) and Central and South America.

Original languageEnglish (US)
Pages (from-to)2279-2286
Number of pages8
JournalJournal of General Virology
Volume78
Issue number9
StatePublished - Sep 1997

Fingerprint

Dengue Virus
Molecular Evolution
Phylogeny
Genotype
Viruses
Nucleic Acids
Dominica
Polynesia
West Indies
Central America
Puerto Rico
Sri Lanka
Philippines
Indonesia
South America
Thailand
Amino Acid Substitution
Amino Acids
Proteins

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Lanciotti, R. S., Gubler, D. J., & Trent, D. W. (1997). Molecular evolution and phylogeny of dengue-4 viruses. Journal of General Virology, 78(9), 2279-2286.

Molecular evolution and phylogeny of dengue-4 viruses. / Lanciotti, Robert S.; Gubler, Duane J.; Trent, Dennis W.

In: Journal of General Virology, Vol. 78, No. 9, 09.1997, p. 2279-2286.

Research output: Contribution to journalArticle

Lanciotti, RS, Gubler, DJ & Trent, DW 1997, 'Molecular evolution and phylogeny of dengue-4 viruses', Journal of General Virology, vol. 78, no. 9, pp. 2279-2286.
Lanciotti RS, Gubler DJ, Trent DW. Molecular evolution and phylogeny of dengue-4 viruses. Journal of General Virology. 1997 Sep;78(9):2279-2286.
Lanciotti, Robert S. ; Gubler, Duane J. ; Trent, Dennis W. / Molecular evolution and phylogeny of dengue-4 viruses. In: Journal of General Virology. 1997 ; Vol. 78, No. 9. pp. 2279-2286.
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