Molecular mechanisms of amyloid oligomers toxicity

Rakez Kayed, Cristian A. Lasagna-Reeves

    Research output: Chapter in Book/Report/Conference proceedingChapter

    19 Scopus citations

    Abstract

    Amyloid oligomers have emerged as the most toxic species of amyloid-β (Aβ). This hypothesis might explain the lack of correlation between amyloid plaques and memory impairment or cellular dysfunction. However, despite the numerous published research articles supporting the critical role Aβ oligomers in synaptic dysfunction and cell death, the exact definition and mechanism of amyloid oligomers formation and toxicity still elusive. Here we review the evidence supporting the many molecular mechanisms proposed for amyloid oligomers toxicity and suggest that the complexity and dynamic nature of amyloid oligomers may be responsible for the discrepancy among these mechanisms and the proposed cellular targets for amyloid oligomers.

    Original languageEnglish (US)
    Title of host publicationAlzheimer'S Disease
    Subtitle of host publicationAdvances For A New Century
    EditorsGeorge Perry, Xiongwei Zhu, Mark Smith, Aaron Sorensen, Jesus Avila
    Pages67-78
    Number of pages12
    DOIs
    StatePublished - Dec 1 2012

    Publication series

    NameAdvances in Alzheimer's Disease
    Volume3
    ISSN (Print)2210-5727
    ISSN (Electronic)2210-5735

    Keywords

    • Alzheimer's disease
    • amyloid
    • amyloid oligomers
    • amyloid toxicity

    ASJC Scopus subject areas

    • Clinical Neurology

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