Molecular mechanisms of amyloid oligomers toxicity

Rakez Kayed, Cristian A. Lasagna-Reeves

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)

Abstract

Amyloid oligomers have emerged as the most toxic species of amyloid-β (Aβ). This hypothesis might explain the lack of correlation between amyloid plaques and memory impairment or cellular dysfunction. However, despite the numerous published research articles supporting the critical role Aβ oligomers in synaptic dysfunction and cell death, the exact definition and mechanism of amyloid oligomers formation and toxicity still elusive. Here we review the evidence supporting the many molecular mechanisms proposed for amyloid oligomers toxicity and suggest that the complexity and dynamic nature of amyloid oligomers may be responsible for the discrepancy among these mechanisms and the proposed cellular targets for amyloid oligomers.

Original languageEnglish (US)
Title of host publicationAdvances in Alzheimer's Disease
Pages67-78
Number of pages12
Volume3
DOIs
StatePublished - 2012

Publication series

NameAdvances in Alzheimer's Disease
Volume3
ISSN (Print)22105727
ISSN (Electronic)22105735

Fingerprint

Amyloid
Poisons
Amyloid Plaques
Cell Death
Research

Keywords

  • Alzheimer's disease
  • amyloid
  • amyloid oligomers
  • amyloid toxicity

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Kayed, R., & Lasagna-Reeves, C. A. (2012). Molecular mechanisms of amyloid oligomers toxicity. In Advances in Alzheimer's Disease (Vol. 3, pp. 67-78). (Advances in Alzheimer's Disease; Vol. 3). https://doi.org/10.3233/978-1-61499-154-0-67

Molecular mechanisms of amyloid oligomers toxicity. / Kayed, Rakez; Lasagna-Reeves, Cristian A.

Advances in Alzheimer's Disease. Vol. 3 2012. p. 67-78 (Advances in Alzheimer's Disease; Vol. 3).

Research output: Chapter in Book/Report/Conference proceedingChapter

Kayed, R & Lasagna-Reeves, CA 2012, Molecular mechanisms of amyloid oligomers toxicity. in Advances in Alzheimer's Disease. vol. 3, Advances in Alzheimer's Disease, vol. 3, pp. 67-78. https://doi.org/10.3233/978-1-61499-154-0-67
Kayed R, Lasagna-Reeves CA. Molecular mechanisms of amyloid oligomers toxicity. In Advances in Alzheimer's Disease. Vol. 3. 2012. p. 67-78. (Advances in Alzheimer's Disease). https://doi.org/10.3233/978-1-61499-154-0-67
Kayed, Rakez ; Lasagna-Reeves, Cristian A. / Molecular mechanisms of amyloid oligomers toxicity. Advances in Alzheimer's Disease. Vol. 3 2012. pp. 67-78 (Advances in Alzheimer's Disease).
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