Molecular mechanisms of amyloid oligomers toxicity

Rakez Kayed, Cristian A. Lasagna-Reeves

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Scopus citations

Abstract

Amyloid oligomers have emerged as the most toxic species of amyloid-β (Aβ). This hypothesis might explain the lack of correlation between amyloid plaques and memory impairment or cellular dysfunction. However, despite the numerous published research articles supporting the critical role Aβ oligomers in synaptic dysfunction and cell death, the exact definition and mechanism of amyloid oligomers formation and toxicity still elusive. Here we review the evidence supporting the many molecular mechanisms proposed for amyloid oligomers toxicity and suggest that the complexity and dynamic nature of amyloid oligomers may be responsible for the discrepancy among these mechanisms and the proposed cellular targets for amyloid oligomers.

Original languageEnglish (US)
Title of host publicationAlzheimer'S Disease
Subtitle of host publicationAdvances For A New Century
EditorsGeorge Perry, Xiongwei Zhu, Mark Smith, Aaron Sorensen, Jesus Avila
Pages67-78
Number of pages12
DOIs
StatePublished - Dec 1 2012

Publication series

NameAdvances in Alzheimer's Disease
Volume3
ISSN (Print)2210-5727
ISSN (Electronic)2210-5735

Keywords

  • Alzheimer's disease
  • amyloid
  • amyloid oligomers
  • amyloid toxicity

ASJC Scopus subject areas

  • Clinical Neurology

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  • Cite this

    Kayed, R., & Lasagna-Reeves, C. A. (2012). Molecular mechanisms of amyloid oligomers toxicity. In G. Perry, X. Zhu, M. Smith, A. Sorensen, & J. Avila (Eds.), Alzheimer'S Disease: Advances For A New Century (pp. 67-78). (Advances in Alzheimer's Disease; Vol. 3). https://doi.org/10.3233/978-1-61499-154-0-67