Molecular mechanisms of head and neck cancer

Marxa L. Figueiredo, Yong Kim, Xiaofeng C. Zhou, Jeffrey N. Myers, David D T Wong

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer worldwide and the overall 50% five-year survival rate is among the lowest of the major cancers. Alterations in cellular molecules controlling DNA repair, proliferation, apoptosis, invasion and angiogenesis are known to contribute to the development of HNSCC. This review will focus on the molecular changes contributing to the pathogenesis of HNSCC and their clinical implications in designing new therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)273-281
Number of pages9
JournalDrug Discovery Today: Disease Mechanisms
Volume1
Issue number2
DOIs
StatePublished - Nov 2004
Externally publishedYes

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ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine

Cite this

Figueiredo, M. L., Kim, Y., Zhou, X. C., Myers, J. N., & Wong, D. D. T. (2004). Molecular mechanisms of head and neck cancer. Drug Discovery Today: Disease Mechanisms, 1(2), 273-281. https://doi.org/10.1016/j.ddmec.2004.10.003