Molecular network and chromosomal clustering of genes involved in synaptic plasticity in the hippocampus

Sin Park Chang, Ruomu Gong, Joshua Stuart, Shao-Jun Tang

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Gene transcription is required for establishing and maintaining the enduring form of long term potentiation (LTP). However, the transcriptome and its associated molecular programs that support LTP are not well understood. The purpose of this study was to identify activity-regulated genes (ARGs) and their molecular pathways that are modulated by LTP induction and to investigate the genomic mechanism for coordinating the transcription of ARGs. We performed time course DNA microarray analyses on the mouse dentate gyrus to determine the temporal genomic expression profiles of ARGs in response to LTP-inducing tetanic stimulation. Our studies uncovered ARGs that regulate various cellular processes, including the structure and function of the synapse, and offered an overview of the dynamic molecular programs that are probably important for LTP. Surprisingly, we found that ARGs are clustered on chromosomes, and ARG clusters are conserved during evolution. Although ARGs in the same cluster have apparently different molecular properties, they are functionally correlated by regulating LTP. In addition, ARGs in specific clusters are co-regulated by the cAMP-response element-binding protein. We propose that chromosomal clustering provides a genomic mechanism for coordinating the transcription of ARGs involved in LTP.

Original languageEnglish (US)
Pages (from-to)30195-30211
Number of pages17
JournalJournal of Biological Chemistry
Volume281
Issue number40
DOIs
StatePublished - Oct 6 2006
Externally publishedYes

Fingerprint

Neuronal Plasticity
Long-Term Potentiation
Plasticity
Cluster Analysis
Hippocampus
Genes
Transcription
Cyclic AMP Response Element-Binding Protein
Dentate Gyrus
Molecular Dynamics Simulation
Microarray Analysis
Multigene Family
Oligonucleotide Array Sequence Analysis
Transcriptome
Microarrays
Synapses
Chromosomes
Molecular dynamics

ASJC Scopus subject areas

  • Biochemistry

Cite this

Molecular network and chromosomal clustering of genes involved in synaptic plasticity in the hippocampus. / Chang, Sin Park; Gong, Ruomu; Stuart, Joshua; Tang, Shao-Jun.

In: Journal of Biological Chemistry, Vol. 281, No. 40, 06.10.2006, p. 30195-30211.

Research output: Contribution to journalArticle

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