Molecular regulation of genes encoding xenobiotic-metabolizing enzymes

Mechanisms involving endogenous factors

R. N. Hines, Z. Luo, T. Cresteil, X. Ding, R. A. Prough, J. L. Fitzpatrick, S. L. Ripp, K. C. Falkner, N. L. Ge, A. Levine, Cornelis Elferink

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

It is widely recognized that xenobiotic-metabolizing enzymes play a fundamental role in the basic processes of carcinogenesis and toxicity on one hand, and chemoprevention and drug efficacy on the other. Realization that different factors can profoundly affect the expression of these enzymes at the genome level has resulted in an enhanced appreciation of the importance these genes play in our modern industrialized age. There continues to be rapid proliferation of studies addressing the molecular regulation of these genes. The discovery of common signal transduction pathways and transcription factors that dictate tissue and developmental-specific expression, as well as variation in expression within a given tissue, suggest that there may be significant interaction among these various regulatory systems. This report is a summary of a symposium that was part of the Structure, Function and Regulation of Cytochromes P450 and Xenobiotic Metabolizing Enzymes satellite meeting of the 2000 joint meeting of the American Society for Biochemistry and Molecular Biology, the American Society for Pharmacology and Experimental Therapeutics, the French Pharmacological Society, and the Pharmacological Society of Canada held in Boston, Massachusetts. This symposium brought together several speakers who addressed specific receptor-mediated signal transduction pathways involved in the regulation of xenobiotic-metabolizing enzymes, as well as other molecular mechanisms whereby endogenous factors are involved in controlling tissue- and developmental-specific expression.

Original languageEnglish (US)
Pages (from-to)623-633
Number of pages11
JournalDrug Metabolism and Disposition
Volume29
Issue number5
StatePublished - 2001
Externally publishedYes

Fingerprint

Gene encoding
Xenobiotics
Signal Transduction
Signal transduction
Genes
Enzymes
Tissue
Pharmacology
Chemoprevention
Cytochrome P-450 Enzyme System
Canada
Toxicity
Carcinogenesis
Transcription Factors
Satellites
Genome
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Hines, R. N., Luo, Z., Cresteil, T., Ding, X., Prough, R. A., Fitzpatrick, J. L., ... Elferink, C. (2001). Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: Mechanisms involving endogenous factors. Drug Metabolism and Disposition, 29(5), 623-633.

Molecular regulation of genes encoding xenobiotic-metabolizing enzymes : Mechanisms involving endogenous factors. / Hines, R. N.; Luo, Z.; Cresteil, T.; Ding, X.; Prough, R. A.; Fitzpatrick, J. L.; Ripp, S. L.; Falkner, K. C.; Ge, N. L.; Levine, A.; Elferink, Cornelis.

In: Drug Metabolism and Disposition, Vol. 29, No. 5, 2001, p. 623-633.

Research output: Contribution to journalArticle

Hines, RN, Luo, Z, Cresteil, T, Ding, X, Prough, RA, Fitzpatrick, JL, Ripp, SL, Falkner, KC, Ge, NL, Levine, A & Elferink, C 2001, 'Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: Mechanisms involving endogenous factors', Drug Metabolism and Disposition, vol. 29, no. 5, pp. 623-633.
Hines, R. N. ; Luo, Z. ; Cresteil, T. ; Ding, X. ; Prough, R. A. ; Fitzpatrick, J. L. ; Ripp, S. L. ; Falkner, K. C. ; Ge, N. L. ; Levine, A. ; Elferink, Cornelis. / Molecular regulation of genes encoding xenobiotic-metabolizing enzymes : Mechanisms involving endogenous factors. In: Drug Metabolism and Disposition. 2001 ; Vol. 29, No. 5. pp. 623-633.
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