Monitoring of lipodystrophic and metabolic abnormalities in HIV-1 infected children on antiretroviral therapy

Vana Spoulou, Christina Kanaka-Gantenbein, Irini Bathrellou, Stefano Mora, Glyceria Mostrou, Lambros Sidossis, George Chrousos, Maria Theodoridou

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

OBJECTIVE: Few studies have thus far assessed body composition by dual energy X-ray absorptrometry (DXA) in children with HIV, primarily because reference data for normally growing children and adolescents are not available. Our study aimed at evaluating body composition in children with HIV and their relation to serum lipids and glucose homeostasis. DESIGN: Body composition was assessed by DXA in 17 HIV-1 infected children at entrance to the study and after 12 months and in one hundred fifty nine age, gender, body mass index (BMI), and Tanner stage matched healthy subjects who served as controls. Lipodystrophy was diagnosed if the trunk/leg fat ratio was out of the range of the expected mean±1SD of the controls. RESULTS: At study entry, 10 patients (7 girls) had developed lipohypertrophy, whereas all remaining patients had lipoatrophy. Lipohypertrophy was associated with older age (p=0.027). Lipodystrophic phenotype was stable in all patients except in one over the 12-month period of follow-up while on continuous antiretroviral therapy (ART). 80% and 70% of patients with lipohypertrophy had triglycerides and cholesterol levels, respectively above the 75th percentile, while 57% and 43% of patients with lipoatrophy had triglycerides and cholesterol, respectively greater than the 75th percentile. High triglycerides were associated with the use of protease inhibitors (p=0.028). Basal fasting glucose and homeostasis model assessment (HOMA) values were within normal limits. CONCL USIONS: HIV-infected paediatric patients on continuous ART developed significant and persistent body composition changes which were associated with dyslipidemia without overt abnormalities of glucose metabolism.

Original languageEnglish (US)
Pages (from-to)149-155
Number of pages7
JournalHormones
Volume10
Issue number2
StatePublished - Apr 2011
Externally publishedYes

Fingerprint

HIV-1
Body Composition
Triglycerides
HIV
Glucose
Homeostasis
Therapeutics
Cholesterol
X-Rays
Lipodystrophy
Dyslipidemias
Protease Inhibitors
Fasting
Leg
Healthy Volunteers
Body Mass Index
Fats
Pediatrics
Phenotype
Lipids

Keywords

  • Antiretroviral therapy
  • Children
  • DXA
  • Dyslipidemia
  • HIV
  • Lipodystrophy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Spoulou, V., Kanaka-Gantenbein, C., Bathrellou, I., Mora, S., Mostrou, G., Sidossis, L., ... Theodoridou, M. (2011). Monitoring of lipodystrophic and metabolic abnormalities in HIV-1 infected children on antiretroviral therapy. Hormones, 10(2), 149-155.

Monitoring of lipodystrophic and metabolic abnormalities in HIV-1 infected children on antiretroviral therapy. / Spoulou, Vana; Kanaka-Gantenbein, Christina; Bathrellou, Irini; Mora, Stefano; Mostrou, Glyceria; Sidossis, Lambros; Chrousos, George; Theodoridou, Maria.

In: Hormones, Vol. 10, No. 2, 04.2011, p. 149-155.

Research output: Contribution to journalArticle

Spoulou, V, Kanaka-Gantenbein, C, Bathrellou, I, Mora, S, Mostrou, G, Sidossis, L, Chrousos, G & Theodoridou, M 2011, 'Monitoring of lipodystrophic and metabolic abnormalities in HIV-1 infected children on antiretroviral therapy', Hormones, vol. 10, no. 2, pp. 149-155.
Spoulou V, Kanaka-Gantenbein C, Bathrellou I, Mora S, Mostrou G, Sidossis L et al. Monitoring of lipodystrophic and metabolic abnormalities in HIV-1 infected children on antiretroviral therapy. Hormones. 2011 Apr;10(2):149-155.
Spoulou, Vana ; Kanaka-Gantenbein, Christina ; Bathrellou, Irini ; Mora, Stefano ; Mostrou, Glyceria ; Sidossis, Lambros ; Chrousos, George ; Theodoridou, Maria. / Monitoring of lipodystrophic and metabolic abnormalities in HIV-1 infected children on antiretroviral therapy. In: Hormones. 2011 ; Vol. 10, No. 2. pp. 149-155.
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abstract = "OBJECTIVE: Few studies have thus far assessed body composition by dual energy X-ray absorptrometry (DXA) in children with HIV, primarily because reference data for normally growing children and adolescents are not available. Our study aimed at evaluating body composition in children with HIV and their relation to serum lipids and glucose homeostasis. DESIGN: Body composition was assessed by DXA in 17 HIV-1 infected children at entrance to the study and after 12 months and in one hundred fifty nine age, gender, body mass index (BMI), and Tanner stage matched healthy subjects who served as controls. Lipodystrophy was diagnosed if the trunk/leg fat ratio was out of the range of the expected mean±1SD of the controls. RESULTS: At study entry, 10 patients (7 girls) had developed lipohypertrophy, whereas all remaining patients had lipoatrophy. Lipohypertrophy was associated with older age (p=0.027). Lipodystrophic phenotype was stable in all patients except in one over the 12-month period of follow-up while on continuous antiretroviral therapy (ART). 80{\%} and 70{\%} of patients with lipohypertrophy had triglycerides and cholesterol levels, respectively above the 75th percentile, while 57{\%} and 43{\%} of patients with lipoatrophy had triglycerides and cholesterol, respectively greater than the 75th percentile. High triglycerides were associated with the use of protease inhibitors (p=0.028). Basal fasting glucose and homeostasis model assessment (HOMA) values were within normal limits. CONCL USIONS: HIV-infected paediatric patients on continuous ART developed significant and persistent body composition changes which were associated with dyslipidemia without overt abnormalities of glucose metabolism.",
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AU - Mostrou, Glyceria

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