Monitoring of tissue optical properties using OCT: Application for blood glucose analysis

Kirill V. Larin, Mohsen S. Eledrisi, Taras V. Ashitkov, Massoud Motamedi, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

Noninvasive monitoring of tissue optical properties in real time could significantly improve diagnostics and management of various diseases. Recently we proposed to use high-resolution Optical Coherence Tomography (OCT) technique for measurement of tissue scattering coefficient at the depth of up to 1 mm. Our pilot studies performed in vitro and in vivo demonstrated that measurement of tissue scattering with this technique can potentially be applied for noninvasive monitoring of blood glucose concentration. High resolution and coherent photon detection of the OCT technique allowed detection of glucose-induced changes in the scattering coefficient. In this paper we report results of in vivo studies performed in dog, New Zealand rabbits, and first human subjects. OCT system with the wavelength of 1300 nm was used in our experiments. OCT signal slope was measured and compared with actual blood glucose concentration. Bolus glucose injections and glucose clamping administrations were used in animal studies. OCT signals were recorded from human subjects during oral glucose tolerance tests. Results obtained from both animal and human studies show good correlation between slope of the OCT signals and actual blood glucose concentration measured using standard glucometers. Sensitivity and accuracy of blood glucose concentration monitoring with the OCT is discussed. Obtained results suggest that OCT is a promising technique for noninvasive monitoring of tissue analytes including glucose.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsV.V. Tuchin
Pages181-188
Number of pages8
Volume4707
DOIs
StatePublished - 2002
EventSaratov Fall Meeting 2001: Optical Technologies in Biophysics and Medicine III - Saratov, Russian Federation
Duration: Oct 2 2001Oct 5 2001

Other

OtherSaratov Fall Meeting 2001: Optical Technologies in Biophysics and Medicine III
CountryRussian Federation
CitySaratov
Period10/2/0110/5/01

Fingerprint

Optical tomography
glucose
blood
Glucose
Blood
Optical properties
tomography
Tissue
optical properties
Monitoring
scattering coefficients
Scattering
animals
Animals
slopes
dogs
high resolution
rabbits
New Zealand
Photons

Keywords

  • Animals
  • Blood glucose
  • Human
  • Noninvasive
  • OCT

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Larin, K. V., Eledrisi, M. S., Ashitkov, T. V., Motamedi, M., & Esenaliev, R. (2002). Monitoring of tissue optical properties using OCT: Application for blood glucose analysis. In V. V. Tuchin (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4707, pp. 181-188) https://doi.org/10.1117/12.475628

Monitoring of tissue optical properties using OCT : Application for blood glucose analysis. / Larin, Kirill V.; Eledrisi, Mohsen S.; Ashitkov, Taras V.; Motamedi, Massoud; Esenaliev, Rinat.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / V.V. Tuchin. Vol. 4707 2002. p. 181-188.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Larin, KV, Eledrisi, MS, Ashitkov, TV, Motamedi, M & Esenaliev, R 2002, Monitoring of tissue optical properties using OCT: Application for blood glucose analysis. in VV Tuchin (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4707, pp. 181-188, Saratov Fall Meeting 2001: Optical Technologies in Biophysics and Medicine III, Saratov, Russian Federation, 10/2/01. https://doi.org/10.1117/12.475628
Larin KV, Eledrisi MS, Ashitkov TV, Motamedi M, Esenaliev R. Monitoring of tissue optical properties using OCT: Application for blood glucose analysis. In Tuchin VV, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4707. 2002. p. 181-188 https://doi.org/10.1117/12.475628
Larin, Kirill V. ; Eledrisi, Mohsen S. ; Ashitkov, Taras V. ; Motamedi, Massoud ; Esenaliev, Rinat. / Monitoring of tissue optical properties using OCT : Application for blood glucose analysis. Proceedings of SPIE - The International Society for Optical Engineering. editor / V.V. Tuchin. Vol. 4707 2002. pp. 181-188
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