Monitoring patients with ARDS, Part 1: How to measure respiratory mechanics. Strategies to enhance the benefits of mechanical ventilation and lessen complications

A. G. Duarte, A. Bidani

Research output: Contribution to journalReview article


Large inspiratory tidal volume, rather than high peak airway pressure (Ppeak), may be responsible for ventilator-associated lung injury in patients with acute respiratory distress syndrome (ARDS). Sustained increases in Ppeak are, however, a nonspecific marker of airway complications and should be investigated. Plateau pressure (Pplat) is useful as an approximation of alveolar pressure; it should not exceed 35 cm H2O. Limiting Pplat by using smaller tidal volumes appears to mitigate the potential for lung injury and may reduce ARDS-related mortality. Intrinsic positive end-expiratory pressure (PEEP) can cause hemodynamic compromise; to detect it, an end-expiratory hold maneuver is performed. Applying external PEEP according to the location of the lower inflection point of the pressure-volume curve may improve oxygenation while helping to avoid barotrauma.

Original languageEnglish (US)
Pages (from-to)140-150
Number of pages11
JournalJournal of Critical Illness
Issue number3
StatePublished - Jan 1 2000


ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this