Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen

Heather A. Baird, Andre J. Marozsan, Michael M. Lederman, Alan Landay, Donna Mildvan, Daniel R. Kuritzkes, Harold A. Kessler, Eric J. Arts

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot to monitor the processing of p55gag precursor into the mature p24 capsid immediately following the first dosage of a PI-containing treatment regimen. Evidence of PI activity was observed in plasma virus as early as 72 hours post treatment-initiation and was predictive of plasma viral RNA decrease at 4 weeks.

Original languageEnglish (US)
Article number2
JournalAIDS Research and Therapy
Volume2
Issue number1
DOIs
StatePublished - Apr 12 2005
Externally publishedYes

Keywords

  • HIV-1
  • p24 antigen capture
  • Protease inhibitors

ASJC Scopus subject areas

  • Molecular Medicine
  • Virology
  • Pharmacology (medical)

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