Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen

Heather A. Baird; Andre J. Marozsan; Michael M. Lederman; Alan Landay; Donna Mildvan; Daniel R. Kuritzkes; Harold A. Kessler; Eric J. Arts

doi:10.1186/1742-6405-2-2

Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen

Heather A. Baird
, Andre J. Marozsan
, Michael M. Lederman
, Alan Landay
, Donna Mildvan
, Daniel R. Kuritzkes
, Harold A. Kessler
, Eric J. Arts

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot to monitor the processing of p55^gag precursor into the mature p24 capsid immediately following the first dosage of a PI-containing treatment regimen. Evidence of PI activity was observed in plasma virus as early as 72 hours post treatment-initiation and was predictive of plasma viral RNA decrease at 4 weeks.

Original language	English (US)
Article number	2
Journal	AIDS Research and Therapy
Volume	2
Issue number	1
DOIs	https://doi.org/10.1186/1742-6405-2-2
State	Published - Apr 12 2005
Externally published	Yes

Keywords

HIV-1
Protease inhibitors
p24 antigen capture

ASJC Scopus subject areas

Molecular Medicine
Virology
Pharmacology (medical)

Access to Document

10.1186/1742-6405-2-2

Cite this

Baird, H. A., Marozsan, A. J., Lederman, M. M., Landay, A., Mildvan, D., Kuritzkes, D. R., Kessler, H. A., & Arts, E. J. (2005). Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen. AIDS Research and Therapy, 2(1), Article 2. https://doi.org/10.1186/1742-6405-2-2

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abstract = "Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot to monitor the processing of p55gag precursor into the mature p24 capsid immediately following the first dosage of a PI-containing treatment regimen. Evidence of PI activity was observed in plasma virus as early as 72 hours post treatment-initiation and was predictive of plasma viral RNA decrease at 4 weeks.",

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AU - Baird, Heather A.

AU - Marozsan, Andre J.

AU - Lederman, Michael M.

AU - Landay, Alan

AU - Mildvan, Donna

AU - Kuritzkes, Daniel R.

AU - Kessler, Harold A.

AU - Arts, Eric J.

PY - 2005/4/12

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N2 - Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot to monitor the processing of p55gag precursor into the mature p24 capsid immediately following the first dosage of a PI-containing treatment regimen. Evidence of PI activity was observed in plasma virus as early as 72 hours post treatment-initiation and was predictive of plasma viral RNA decrease at 4 weeks.

AB - Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot to monitor the processing of p55gag precursor into the mature p24 capsid immediately following the first dosage of a PI-containing treatment regimen. Evidence of PI activity was observed in plasma virus as early as 72 hours post treatment-initiation and was predictive of plasma viral RNA decrease at 4 weeks.

KW - HIV-1

KW - Protease inhibitors

KW - p24 antigen capture

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UR - https://www.scopus.com/pages/publications/33845194705#tab=citedBy

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ER -

Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen

Abstract

Keywords

ASJC Scopus subject areas

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