Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT

Kirill V. Larin, Rinat Esenaliev, Eunha Kim, Sanghoon Oh, Massoud Motamedi, Thomas E. Milner

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Functional imaging of clear and tissue-simulating phantoms using phase-resolved swept-source spectroscopic OCT (PhS-SSOCT) is described. Superior sensitivity of PhS-SSOCT technique to monitor ultra-small changes in sample refractive index is demonstrated using aqueous solutions of glucose and aqueous suspensions of polystyrene microspheres and glucose. Glucose-induced changes in the phase are found to be 0.039 rad/mM and 0.037 rad/mM in the 200 μm-thick cell for clear and turbid media, respectively, that is in good agreement with our previous data obtained using differential-phase time-domain OCT. Obtained results suggest that PhS-SSOCT has a potential for noninvasive, depth-resolved, real-time quantitative monitoring of concentrations of glucose and other analytes with high accuracy.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsV.V. Tuchin, J.A. Izatt, J.G. Fujimoto
Pages422-425
Number of pages4
Volume5690
DOIs
StatePublished - 2005
EventCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX - San Jose, CA, United States
Duration: Jan 23 2005Jan 26 2005

Other

OtherCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX
CountryUnited States
CitySan Jose, CA
Period1/23/051/26/05

Fingerprint

Glucose
Refractive index
Monitoring
Microspheres
Polystyrenes
Tissue
Imaging techniques

Keywords

  • OCT
  • Phase measurements
  • Swept-source

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Larin, K. V., Esenaliev, R., Kim, E., Oh, S., Motamedi, M., & Milner, T. E. (2005). Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT. In V. V. Tuchin, J. A. Izatt, & J. G. Fujimoto (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 5690, pp. 422-425). [70] https://doi.org/10.1117/12.590534

Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT. / Larin, Kirill V.; Esenaliev, Rinat; Kim, Eunha; Oh, Sanghoon; Motamedi, Massoud; Milner, Thomas E.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / V.V. Tuchin; J.A. Izatt; J.G. Fujimoto. Vol. 5690 2005. p. 422-425 70.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Larin, KV, Esenaliev, R, Kim, E, Oh, S, Motamedi, M & Milner, TE 2005, Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT. in VV Tuchin, JA Izatt & JG Fujimoto (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 5690, 70, pp. 422-425, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, San Jose, CA, United States, 1/23/05. https://doi.org/10.1117/12.590534
Larin KV, Esenaliev R, Kim E, Oh S, Motamedi M, Milner TE. Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT. In Tuchin VV, Izatt JA, Fujimoto JG, editors, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 5690. 2005. p. 422-425. 70 https://doi.org/10.1117/12.590534
Larin, Kirill V. ; Esenaliev, Rinat ; Kim, Eunha ; Oh, Sanghoon ; Motamedi, Massoud ; Milner, Thomas E. / Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. editor / V.V. Tuchin ; J.A. Izatt ; J.G. Fujimoto. Vol. 5690 2005. pp. 422-425
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