Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling

Keyphrases

• Mammalian Target of Rapamycin Signaling 100%
• Stress-induced 100%
• Chronic Stress 100%
• Depressive-like Behavior 100%
• Monoacylglycerol Lipase Inhibition 100%
• Chronic Mild Stress 83%
• JZL184 83%
• Hippocampus 66%
• 2-Arachidonoylglycerol (2-AG) 50%
• Endocannabinoids 50%
• Mammalian Target of Rapamycin (mTOR) 33%
• Antidepressants 33%
• Endocannabinoid System 33%
• Monoacylglycerol Lipase Inhibitors 33%
• Pathophysiology 16%
• Genomic Deletion 16%
• Adeno-associated Viral Vector 16%
• Behavioral Abnormalities 16%
• Pyramidal Neurons 16%
• Synaptic Depression 16%
• Biochemical Abnormalities 16%
• Cannabinoid Receptor 1 (CB1R) 16%
• Stress Coping 16%
• Stress Decrease 16%
• Monoacylglycerol Lipase 16%
• Cre Recombinase 16%
• Emotion-focused Coping 16%
• Stress Dysregulation 16%
• Mouse Model of Depression 16%
• Depolarization-induced Suppression of Excitation 16%

Neuroscience

• Behavior (Neuroscience) 100%
• Mammalian Target of Rapamycin 100%
• Acylglycerol Lipase 100%
• Hippocampus 80%
• Endocannabinoid 60%
• 2-Arachidonoylglycerol 60%
• Antidepressant 40%
• Lipase Inhibitors 40%
• Endocannabinoid System 40%
• Adeno Associated Virus Vector 20%
• Gene Deletion 20%
• Cre Recombinase 20%
• Receptor 20%
• Cannabinoid 20%

Biochemistry, Genetics and Molecular Biology

• Mechanistic Target of Rapamycin 100%
• Chronic Stress 100%
• Monoacylglycerol Lipase 100%
• 2-Arachidonoylglycerol 60%
• Endocannabinoid System 40%
• Mouse Model 20%
• Gene Deletion 20%
• Adeno Associated Virus Vector 20%
• Cre Recombinase 20%
• Depolarization-Induced Suppression of Inhibition 20%
• Cannabinoid 20%
• Coping Behavior 20%
• Deficiency 20%