Monoclonal antibodies to Afipia felis - A putative agent of cat scratch disease

X. Yu, D. Raoult

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Twelve hybridoma clones producing monoclonal antibodies to Afipia felis, a putative causative agent of cat scratch disease, were derived from BALB/c mice immunized with A felis. All 12 monoclonal antibodies were species- specific for A felis and reacted with lipopolysaccharide antigens of A felis. These monoclonal antibodies belong to immunoglobulin (Ig) G1, IgG2a, IgG2b, IgG3, and IgM isotypes. All monoclonal antibodies reacted with both agar- grown A felis and tissue culture-propagated A felis. Formalin fixation did not alter the reactivity of the antigen with the monoclonal antibodies. These monoclonal antibodies could be a useful tool for investigation of the disputed role of A felis in cat scratch disease.

Original languageEnglish (US)
Pages (from-to)603-606
Number of pages4
JournalAmerican journal of clinical pathology
Volume101
Issue number5
DOIs
StatePublished - Jan 1 1994

Keywords

  • Afipia felis
  • Cat scratch disease
  • Monoclonal antibody

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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