Monocyte maturation, HIV susceptibility, and transmigration across the blood brain barrier are critical in HIV neuropathogenesis

Dionna W. Williams, Eliseo Eugenin, Tina M. Calderon, Joan W. Berman

Research output: Contribution to journalReview article

100 Citations (Scopus)

Abstract

HIV continues to be a global health crisis with more than 34 million people infected worldwide (UNAIDS: Report on the Global AIDS Epidemic 2010, Geneva, World Health Organization). HIV enters the CNS within 2 weeks of infection and establishes a spectrum of HAND in a large percentage of infected individuals. These neurologic deficits greatly impact the quality of life of those infected with HIV. The establishment of HAND is largely attributed to monocyte transmigration, particularly that of a mature CD14 +CD16 + monocyte population, which is more susceptible to HIV infection, across the BBB into the CNS parenchyma in response to chemotactic signals. To enter the CNS, junctional proteins on the monocytes must participate in homo- and heterotypic interactions with those present on BMVECs of the BBB as they transmigrate across the barrier. This transmigration is responsible for bringing virus into the brain and establishing chronic neuroinflammation. While there is baseline trafficking of monocytes into the CNS, the increased chemotactic signals present during HIV infection of the brain promote exuberant monocyte transmigration into the CNS. This review will discuss the mechanisms of monocyte differentiation/maturation, HIV infectivity, and transmigration into the CNS parenchyma that contribute to the establishment of cognitive impairment in HIV-infected individuals. It will focus on markers of monocyte subpopulations, how differentiation/ maturation alters HIV infectivity, and the mechanisms that promote their increased transmigration across the BBB into the CNS.

Original languageEnglish (US)
Pages (from-to)401-415
Number of pages15
JournalJournal of Leukocyte Biology
Volume91
Issue number3
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

Fingerprint

Blood-Brain Barrier
Monocytes
HIV
HIV Infections
Brain
Neurologic Manifestations
Acquired Immunodeficiency Syndrome
Quality of Life
Viruses
Infection
Population
Proteins

Keywords

  • Brain
  • CD
  • Dementia
  • HAND

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Monocyte maturation, HIV susceptibility, and transmigration across the blood brain barrier are critical in HIV neuropathogenesis. / Williams, Dionna W.; Eugenin, Eliseo; Calderon, Tina M.; Berman, Joan W.

In: Journal of Leukocyte Biology, Vol. 91, No. 3, 01.03.2012, p. 401-415.

Research output: Contribution to journalReview article

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