Monocyte-produced prostaglandin induces Fcγ receptor expression on human T cells

Pawel A. Kaszubowski, James S. Goodwin

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Abstract

Incubation of human T cells for 18 hr with prostaglandin E2 (PGE2 3 × 10-6 M) causes a slight but significant increase in the percentage of Tγ cells and a reduction in Tμ cells. When PGE was added to "non-Tγ" cells, the increase in the percentage of Tγ cells was more marked (from 1.5% Tγ without PGE to 11% Tγ with PGE2, P < 0.001). Supernates from cultures of human monocytes also caused an increase in Tγ cells (10% Tγ without supernate to 18% with supernate, P < 0.01), and this increase was blocked if the monocytes were cultured with indomethacin, a prostaglandin synthetase inhibitor (9% Tγ cells). Thus, monocytes may regulate Fcγ receptors on T cells via PGE2 production.

Original languageEnglish (US)
Pages (from-to)343-348
Number of pages6
JournalCellular Immunology
Volume68
Issue number2
DOIs
StatePublished - Apr 1982
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

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