Monocyte-produced prostaglandin induces Fcγ receptor expression on human T cells

Pawel A. Kaszubowski, James Goodwin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Incubation of human T cells for 18 hr with prostaglandin E2 (PGE2 3 × 10-6 M) causes a slight but significant increase in the percentage of Tγ cells and a reduction in Tμ cells. When PGE was added to "non-Tγ" cells, the increase in the percentage of Tγ cells was more marked (from 1.5% Tγ without PGE to 11% Tγ with PGE2, P < 0.001). Supernates from cultures of human monocytes also caused an increase in Tγ cells (10% Tγ without supernate to 18% with supernate, P < 0.01), and this increase was blocked if the monocytes were cultured with indomethacin, a prostaglandin synthetase inhibitor (9% Tγ cells). Thus, monocytes may regulate Fcγ receptors on T cells via PGE2 production.

Original languageEnglish (US)
Pages (from-to)343-348
Number of pages6
JournalCellular Immunology
Volume68
Issue number2
DOIs
StatePublished - 1982
Externally publishedYes

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Fc Receptors
Prostaglandins
Monocytes
T-Lymphocytes
Dinoprostone
Prostaglandins E
Prostaglandin Antagonists
Prostaglandin-Endoperoxide Synthases
Indomethacin

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Monocyte-produced prostaglandin induces Fcγ receptor expression on human T cells. / Kaszubowski, Pawel A.; Goodwin, James.

In: Cellular Immunology, Vol. 68, No. 2, 1982, p. 343-348.

Research output: Contribution to journalArticle

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