TY - JOUR
T1 - Monocyte-produced prostaglandin induces Fcγ receptor expression on human T cells
AU - Kaszubowski, Pawel A.
AU - Goodwin, James S.
PY - 1982/4
Y1 - 1982/4
N2 - Incubation of human T cells for 18 hr with prostaglandin E2 (PGE2 3 × 10-6 M) causes a slight but significant increase in the percentage of Tγ cells and a reduction in Tμ cells. When PGE was added to "non-Tγ" cells, the increase in the percentage of Tγ cells was more marked (from 1.5% Tγ without PGE to 11% Tγ with PGE2, P < 0.001). Supernates from cultures of human monocytes also caused an increase in Tγ cells (10% Tγ without supernate to 18% with supernate, P < 0.01), and this increase was blocked if the monocytes were cultured with indomethacin, a prostaglandin synthetase inhibitor (9% Tγ cells). Thus, monocytes may regulate Fcγ receptors on T cells via PGE2 production.
AB - Incubation of human T cells for 18 hr with prostaglandin E2 (PGE2 3 × 10-6 M) causes a slight but significant increase in the percentage of Tγ cells and a reduction in Tμ cells. When PGE was added to "non-Tγ" cells, the increase in the percentage of Tγ cells was more marked (from 1.5% Tγ without PGE to 11% Tγ with PGE2, P < 0.001). Supernates from cultures of human monocytes also caused an increase in Tγ cells (10% Tγ without supernate to 18% with supernate, P < 0.01), and this increase was blocked if the monocytes were cultured with indomethacin, a prostaglandin synthetase inhibitor (9% Tγ cells). Thus, monocytes may regulate Fcγ receptors on T cells via PGE2 production.
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U2 - 10.1016/0008-8749(82)90118-6
DO - 10.1016/0008-8749(82)90118-6
M3 - Article
C2 - 6212125
AN - SCOPUS:0020056587
SN - 0008-8749
VL - 68
SP - 343
EP - 348
JO - Cellular Immunology
JF - Cellular Immunology
IS - 2
ER -