Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting Rho GTPases and extracellular signal-regulated kinase signaling pathways

Keyphrases

• Angiogenesis 16%
• Anti-inflammatory Properties 8%
• Antiangiogenic Activity 8%
• Anticancer Action 8%
• Antioxidant System 8%
• Aortic Ring Assay 8%
• Biflavonoids 100%
• Cancer Treatment 8%
• Cancer Tumor 8%
• Capillary-like Tube Formation 8%
• Cdc42 GTPase 8%
• Cell Proliferation 8%
• Dose Effect 8%
• Endothelial Cells 8%
• Extracellular Signal-regulated Kinase Pathway 8%
• Extracellular Signal-regulated Kinase Signaling Pathway 100%
• Garcinia Dulcis 8%
• Human Umbilical Vein Endothelial Cells (HUVECs) 8%
• In Cancer 8%
• Inhibit Tumor 100%
• Inhibitory Effect 8%
• Matrigel Plug Assay 8%
• Microvessels 16%
• Migration Invasion 8%
• Mitogen-activated Protein Kinase/extracellular Signal-regulated Kinase 8%
• Morelloflavone 100%
• Mouse Tumor Model 8%
• Novel Functions 8%
• PC-3 8%
• Phosphorylation 8%
• Proliferation Migration 8%
• Prostate Cancer Cells 8%
• Rac GTPase 8%
• Rho GTPases 100%
• Tumor Angiogenesis 100%
• Tumor Growth 25%
• Tumor Invasiveness 8%
• Tumor Metastasis 8%
• Tumorigenesis 8%
• Vascular Endothelial Growth Factor 16%
• Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) 8%
• Xenograft Mice 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Anti-Inflammatory Drug 20%
• Antiangiogenic 20%
• Antioxidant 20%
• Antivirus Agent 20%
• Biflavonoid 100%
• Carcinogenesis 20%
• Garcinia 20%
• Guanosine Triphosphatase 20%
• Malignant Neoplasm 20%
• Matrigel 20%
• Mitogen Activated Protein Kinase 100%
• Neoplasm 100%
• Phosphotransferase 20%
• Prostate Cancer 20%
• Rho Guanine Nucleotide Binding Protein 100%
• Tumor Growth 60%
• Tumor Model 20%
• Vasculotropin 40%
• Vasculotropin Receptor 2 20%