Abstract
The ingestion of a meal in nonruminants disrupts the cycling of migrating myoelectric complexes for several hours. We investigated the initiation of phase III activity during the posprandial state by morphine. Small intestine recordings were made from 5 dogs by surgically implanted electrodes. Morphine boluses (5-400 μg/kg) were given during the fasted state and after a meal. Morphine initiated premature phase III activity in the fasted state and it also initiated phase III activity in the postprandial state. Motilin did not initiate phase III activity in the postprandial state. The mean durations of morphine-initiated phase III activity were not significantly different from that of spontaneous phase III activity; however, morphine-initiated phase III activity in both the fasted and fed states migrated faster than spontaneous phase III activity in the proximal half of small intestine but not in the distal half. The latent period for the initiation of phase III activity was significantly greater 20-40 min after the meal than 2 h after the meal. The minimum dose of morphine required to initiate phase III activity in the fed state decreased progressively after the initial increase until it reached fasted levels 7-10 h after the meal. Spontaneous phase III activity appeared after this period. We conclude that (a) morphine temporarily overcomes the disruption of migrating myoelectric complex cycling after a meal; (b) morphine acts at different sites than motilin to initiate phase III activity; (c) the increased refractoriness of migrating myoelectric complex cycling mechanisms after a meal may play a role in the disruption of migrating myoelectric complex cycling.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 662-669 |
| Number of pages | 8 |
| Journal | Gastroenterology |
| Volume | 86 |
| Issue number | 4 |
| State | Published - 1984 |
| Externally published | Yes |
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- Gastroenterology
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Morphine-initiated migrating myoelectric complexes in the fed state in dogs. / Sarna, S. K.; Condon, R. E.
In: Gastroenterology, Vol. 86, No. 4, 1984, p. 662-669.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Morphine-initiated migrating myoelectric complexes in the fed state in dogs
AU - Sarna, S. K.
AU - Condon, R. E.
PY - 1984
Y1 - 1984
N2 - The ingestion of a meal in nonruminants disrupts the cycling of migrating myoelectric complexes for several hours. We investigated the initiation of phase III activity during the posprandial state by morphine. Small intestine recordings were made from 5 dogs by surgically implanted electrodes. Morphine boluses (5-400 μg/kg) were given during the fasted state and after a meal. Morphine initiated premature phase III activity in the fasted state and it also initiated phase III activity in the postprandial state. Motilin did not initiate phase III activity in the postprandial state. The mean durations of morphine-initiated phase III activity were not significantly different from that of spontaneous phase III activity; however, morphine-initiated phase III activity in both the fasted and fed states migrated faster than spontaneous phase III activity in the proximal half of small intestine but not in the distal half. The latent period for the initiation of phase III activity was significantly greater 20-40 min after the meal than 2 h after the meal. The minimum dose of morphine required to initiate phase III activity in the fed state decreased progressively after the initial increase until it reached fasted levels 7-10 h after the meal. Spontaneous phase III activity appeared after this period. We conclude that (a) morphine temporarily overcomes the disruption of migrating myoelectric complex cycling after a meal; (b) morphine acts at different sites than motilin to initiate phase III activity; (c) the increased refractoriness of migrating myoelectric complex cycling mechanisms after a meal may play a role in the disruption of migrating myoelectric complex cycling.
AB - The ingestion of a meal in nonruminants disrupts the cycling of migrating myoelectric complexes for several hours. We investigated the initiation of phase III activity during the posprandial state by morphine. Small intestine recordings were made from 5 dogs by surgically implanted electrodes. Morphine boluses (5-400 μg/kg) were given during the fasted state and after a meal. Morphine initiated premature phase III activity in the fasted state and it also initiated phase III activity in the postprandial state. Motilin did not initiate phase III activity in the postprandial state. The mean durations of morphine-initiated phase III activity were not significantly different from that of spontaneous phase III activity; however, morphine-initiated phase III activity in both the fasted and fed states migrated faster than spontaneous phase III activity in the proximal half of small intestine but not in the distal half. The latent period for the initiation of phase III activity was significantly greater 20-40 min after the meal than 2 h after the meal. The minimum dose of morphine required to initiate phase III activity in the fed state decreased progressively after the initial increase until it reached fasted levels 7-10 h after the meal. Spontaneous phase III activity appeared after this period. We conclude that (a) morphine temporarily overcomes the disruption of migrating myoelectric complex cycling after a meal; (b) morphine acts at different sites than motilin to initiate phase III activity; (c) the increased refractoriness of migrating myoelectric complex cycling mechanisms after a meal may play a role in the disruption of migrating myoelectric complex cycling.
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M3 - Article
VL - 86
SP - 662
EP - 669
JO - Gastroenterology
JF - Gastroenterology
SN - 0016-5085
IS - 4
ER -