Morphologic and Genetic Characterization of Ilheus Virus, a Potential Emergent Flavivirus in the Americas

Jessica A. Plante, Kenneth S. Plante, Vsevolod L. Popov, Divya P. Shinde, Steven G. Widen, Michaela Buenemann, Mauricio L. Nogueira, Nikos Vasilakis

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Ilheus virus (ILHV) is a mosquito-borne flavivirus circulating throughout Central and South America and the Caribbean. It has been detected in several mosquito genera including Aedes and Culex, and birds are thought to be its primary amplifying and reservoir host. Here, we describe the genomic and morphologic characterization of ten ILHV strains. Our analyses revealed a high conservation of both the 5′- and 3′-untranslated regions but considerable divergence within the open reading frame. We also showed that ILHV displays a typical flavivirus structural and genomic organization. Our work lays the foundation for subsequent ILHV studies to better understand its transmission cycles, pathogenicity, and emergence potential.

Original languageEnglish (US)
Article number195
JournalViruses
Volume15
Issue number1
DOIs
StatePublished - Jan 2023

Keywords

  • ILHV
  • Ilheus virus
  • flavivirus
  • morphologic and genetic characterization

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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