Morphological characteristics of a unique intracytoplasmic neuronal inclusion body

J. D. Butts, T. W. Bouldin, D. H. Walker

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Unique intracytoplasmic inclusion bodies unaccompanied by a clinically apparent neurologic disease were found in the neurons of the hippocampus, subiculum, and mammillary body of a man who died suddenly, presumably of cardiac disease. The eosinophilic inclusions were round and often targetoid, with a central core that had the staining characteristics of RNA. Ultrastructurally, the inclusions were mainly composed of osmiophilic granular material. Rabies viral antigen was not detected by immunofluorescence, and heavy metals were not detected by energy dispersive spectrometry. These neuronal inclusions should be distinguished from Negri bodies.

Original languageEnglish (US)
Pages (from-to)345-347
Number of pages3
JournalActa Neuropathologica
Volume62
Issue number4
DOIs
StatePublished - Dec 1 1984
Externally publishedYes

Keywords

  • Intracytoplasmic inclusion
  • Limbic system
  • Negri-like body
  • Neuron
  • RNA

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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