Morphological characteristics of a unique intracytoplasmic neuronal inclusion body

J. D. Butts, T. W. Bouldin, David Walker

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Unique intracytoplasmic inclusion bodies unaccompanied by a clinically apparent neurologic disease were found in the neurons of the hippocampus, subiculum, and mammillary body of a man who died suddenly, presumably of cardiac disease. The eosinophilic inclusions were round and often targetoid, with a central core that had the staining characteristics of RNA. Ultrastructurally, the inclusions were mainly composed of osmiophilic granular material. Rabies viral antigen was not detected by immunofluorescence, and heavy metals were not detected by energy dispersive spectrometry. These neuronal inclusions should be distinguished from Negri bodies.

Original languageEnglish (US)
Pages (from-to)345-347
Number of pages3
JournalActa Neuropathologica
Volume62
Issue number4
DOIs
StatePublished - Dec 1984
Externally publishedYes

Fingerprint

Inclusion Bodies
Hippocampus
Viral Inclusion Bodies
Mammillary Bodies
Rabies
Viral Antigens
Heavy Metals
Nervous System Diseases
Fluorescent Antibody Technique
Heart Diseases
Spectrum Analysis
RNA
Staining and Labeling
Neurons

Keywords

  • Intracytoplasmic inclusion
  • Limbic system
  • Negri-like body
  • Neuron
  • RNA

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Morphological characteristics of a unique intracytoplasmic neuronal inclusion body. / Butts, J. D.; Bouldin, T. W.; Walker, David.

In: Acta Neuropathologica, Vol. 62, No. 4, 12.1984, p. 345-347.

Research output: Contribution to journalArticle

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