Morphology and morphogenesis of arenaviruses

F. A. Murphy, S. G. Whitfield

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Arenaviruses have unique structural characteristics; they are pleomorphic, have a mean diameter of 110-130 nm, and consist of a membranous envelope with surface projections surrounding an interior containing ribosomes and filaments. Virus particles bud from plasma membranes of infected cells and in many cases large intracytoplasmic inclusion bodies are formed. These characteristics allow generic identification, but no differentiation of individual viruses. Ultrastructural identification of virus particles and pathologic processes in infected tissues of man and experimental animals is important in understanding the nature of arenaviral pathogenesis. Such identification also contributes to the understanding of the mechanisms of viral shedding and transmission in reservoir host species.

Original languageEnglish (US)
Pages (from-to)409-419
Number of pages11
JournalBulletin of the World Health Organization
Issue number4-5 6
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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