Morphometry-based measurements of the structural response to whole-brain radiation

D. Fuentes, J. Contreras, J. Yu, R. He, E. Castillo, R. Castillo, T. Guerrero

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Methods: Pre- and Post-irradiation magnetic resonance imaging (MRI) data sets were retrospectively analyzed in N = 15 patients. Volume changes with respect to pre-irradiation were quantitatively measured in the cerebrum and ventricles. Measurements were correlated with the time interval from irradiation. Criteria for inclusion included craniospinal irradiation, pre-irradiation MRI, at least one follow-up MRI, and no disease progression. The brain on each image was segmented to remove the skull and registered to the initial pre-treatment scan. Average volume changes were measured using morphometry analysis of the deformation Jacobian and direct template registration-based segmentation of brain structures.

Purpose: Morphometry techniques were applied to quantify the normal tissue therapy response in patients receiving whole-brain radiation for intracranial malignancies.

Results: An average cerebral volume atrophy of $$-$$-0.2 and $$-$$-3 % was measured for the deformation morphometry and direct segmentation methods, respectively. An average ventricle volume dilation of 21 and 20 % was measured for the deformation morphometry and direct segmentation methods, respectively.

Conclusion: The presented study has developed an image processing pipeline for morphometric monitoring of brain tissue volume changes as a response to radiation therapy. Results indicate that quantitative morphometric monitoring is feasible and may provide additional information in assessing response.

Original languageEnglish (US)
Pages (from-to)393-401
Number of pages9
JournalInternational journal of computer assisted radiology and surgery
Volume10
Issue number4
DOIs
StatePublished - Apr 1 2015
Externally publishedYes

Fingerprint

Brain
Irradiation
Radiation
Magnetic resonance
Magnetic Resonance Imaging
Imaging techniques
Craniospinal Irradiation
Tissue
Cerebrum
Cell- and Tissue-Based Therapy
Skull
Monitoring
Atrophy
Radiotherapy
Disease Progression
Dilatation
Image processing
Pipelines
Neoplasms
Therapeutics

Keywords

  • Computational anatomy
  • Diffeomorphism
  • Image registration
  • Morphometry
  • Radiation therapy response

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Health Informatics
  • Surgery

Cite this

Morphometry-based measurements of the structural response to whole-brain radiation. / Fuentes, D.; Contreras, J.; Yu, J.; He, R.; Castillo, E.; Castillo, R.; Guerrero, T.

In: International journal of computer assisted radiology and surgery, Vol. 10, No. 4, 01.04.2015, p. 393-401.

Research output: Contribution to journalArticle

Fuentes, D. ; Contreras, J. ; Yu, J. ; He, R. ; Castillo, E. ; Castillo, R. ; Guerrero, T. / Morphometry-based measurements of the structural response to whole-brain radiation. In: International journal of computer assisted radiology and surgery. 2015 ; Vol. 10, No. 4. pp. 393-401.
@article{19b48b82b4714253ad208f9e70314ce9,
title = "Morphometry-based measurements of the structural response to whole-brain radiation",
abstract = "Methods: Pre- and Post-irradiation magnetic resonance imaging (MRI) data sets were retrospectively analyzed in N = 15 patients. Volume changes with respect to pre-irradiation were quantitatively measured in the cerebrum and ventricles. Measurements were correlated with the time interval from irradiation. Criteria for inclusion included craniospinal irradiation, pre-irradiation MRI, at least one follow-up MRI, and no disease progression. The brain on each image was segmented to remove the skull and registered to the initial pre-treatment scan. Average volume changes were measured using morphometry analysis of the deformation Jacobian and direct template registration-based segmentation of brain structures.Purpose: Morphometry techniques were applied to quantify the normal tissue therapy response in patients receiving whole-brain radiation for intracranial malignancies.Results: An average cerebral volume atrophy of $$-$$-0.2 and $$-$$-3 {\%} was measured for the deformation morphometry and direct segmentation methods, respectively. An average ventricle volume dilation of 21 and 20 {\%} was measured for the deformation morphometry and direct segmentation methods, respectively.Conclusion: The presented study has developed an image processing pipeline for morphometric monitoring of brain tissue volume changes as a response to radiation therapy. Results indicate that quantitative morphometric monitoring is feasible and may provide additional information in assessing response.",
keywords = "Computational anatomy, Diffeomorphism, Image registration, Morphometry, Radiation therapy response",
author = "D. Fuentes and J. Contreras and J. Yu and R. He and E. Castillo and R. Castillo and T. Guerrero",
year = "2015",
month = "4",
day = "1",
doi = "10.1007/s11548-014-1128-3",
language = "English (US)",
volume = "10",
pages = "393--401",
journal = "Computer-Assisted Radiology and Surgery",
issn = "1861-6410",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Morphometry-based measurements of the structural response to whole-brain radiation

AU - Fuentes, D.

AU - Contreras, J.

AU - Yu, J.

AU - He, R.

AU - Castillo, E.

AU - Castillo, R.

AU - Guerrero, T.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Methods: Pre- and Post-irradiation magnetic resonance imaging (MRI) data sets were retrospectively analyzed in N = 15 patients. Volume changes with respect to pre-irradiation were quantitatively measured in the cerebrum and ventricles. Measurements were correlated with the time interval from irradiation. Criteria for inclusion included craniospinal irradiation, pre-irradiation MRI, at least one follow-up MRI, and no disease progression. The brain on each image was segmented to remove the skull and registered to the initial pre-treatment scan. Average volume changes were measured using morphometry analysis of the deformation Jacobian and direct template registration-based segmentation of brain structures.Purpose: Morphometry techniques were applied to quantify the normal tissue therapy response in patients receiving whole-brain radiation for intracranial malignancies.Results: An average cerebral volume atrophy of $$-$$-0.2 and $$-$$-3 % was measured for the deformation morphometry and direct segmentation methods, respectively. An average ventricle volume dilation of 21 and 20 % was measured for the deformation morphometry and direct segmentation methods, respectively.Conclusion: The presented study has developed an image processing pipeline for morphometric monitoring of brain tissue volume changes as a response to radiation therapy. Results indicate that quantitative morphometric monitoring is feasible and may provide additional information in assessing response.

AB - Methods: Pre- and Post-irradiation magnetic resonance imaging (MRI) data sets were retrospectively analyzed in N = 15 patients. Volume changes with respect to pre-irradiation were quantitatively measured in the cerebrum and ventricles. Measurements were correlated with the time interval from irradiation. Criteria for inclusion included craniospinal irradiation, pre-irradiation MRI, at least one follow-up MRI, and no disease progression. The brain on each image was segmented to remove the skull and registered to the initial pre-treatment scan. Average volume changes were measured using morphometry analysis of the deformation Jacobian and direct template registration-based segmentation of brain structures.Purpose: Morphometry techniques were applied to quantify the normal tissue therapy response in patients receiving whole-brain radiation for intracranial malignancies.Results: An average cerebral volume atrophy of $$-$$-0.2 and $$-$$-3 % was measured for the deformation morphometry and direct segmentation methods, respectively. An average ventricle volume dilation of 21 and 20 % was measured for the deformation morphometry and direct segmentation methods, respectively.Conclusion: The presented study has developed an image processing pipeline for morphometric monitoring of brain tissue volume changes as a response to radiation therapy. Results indicate that quantitative morphometric monitoring is feasible and may provide additional information in assessing response.

KW - Computational anatomy

KW - Diffeomorphism

KW - Image registration

KW - Morphometry

KW - Radiation therapy response

UR - http://www.scopus.com/inward/record.url?scp=84939975841&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939975841&partnerID=8YFLogxK

U2 - 10.1007/s11548-014-1128-3

DO - 10.1007/s11548-014-1128-3

M3 - Article

C2 - 25408306

AN - SCOPUS:84939975841

VL - 10

SP - 393

EP - 401

JO - Computer-Assisted Radiology and Surgery

JF - Computer-Assisted Radiology and Surgery

SN - 1861-6410

IS - 4

ER -