Mosquito Defense Strategies against Viral Infection

Gong Cheng, Yang Liu, Penghua Wang, Xiaoping Xiao

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations

Abstract

Mosquito-borne viral diseases are a major concern of global health and result in significant economic losses in many countries. As natural vectors, mosquitoes are very permissive to and allow systemic and persistent arbovirus infection. Intriguingly, persistent viral propagation in mosquito tissues neither results in dramatic pathological sequelae nor impairs the vectorial behavior or lifespan, indicating that mosquitoes have evolved mechanisms to tolerate persistent infection and developed efficient antiviral strategies to restrict viral replication to nonpathogenic levels. Here we provide an overview of recent progress in understanding mosquito antiviral immunity and advances in the strategies by which mosquitoes control viral infection in specific tissues.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalTrends in Parasitology
Volume32
Issue number3
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

Keywords

  • Antiviral immunity
  • Arbovirus
  • Mosquito

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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