@article{c6e649e35f1949e58ecbdc6996c8bb3b,
title = "Mosquito Defense Strategies against Viral Infection",
abstract = "Mosquito-borne viral diseases are a major concern of global health and result in significant economic losses in many countries. As natural vectors, mosquitoes are very permissive to and allow systemic and persistent arbovirus infection. Intriguingly, persistent viral propagation in mosquito tissues neither results in dramatic pathological sequelae nor impairs the vectorial behavior or lifespan, indicating that mosquitoes have evolved mechanisms to tolerate persistent infection and developed efficient antiviral strategies to restrict viral replication to nonpathogenic levels. Here we provide an overview of recent progress in understanding mosquito antiviral immunity and advances in the strategies by which mosquitoes control viral infection in specific tissues.",
keywords = "Antiviral immunity, Arbovirus, Mosquito",
author = "Gong Cheng and Yang Liu and Penghua Wang and Xiaoping Xiao",
note = "Funding Information: This work was supported by grants from the National Natural Science Foundation of China to G.C. (81301412, 81422028, and 81571975), the National Key Basic Research Program of MOST to G.C. (2013CB911500), the Excellent Young Scientist Foundation of Beijing to G.C. (2013D009004000002), the Grand Challenges Explorations of the Bill and Melinda Gates Foundation to G.C. (OPP1021992), and the National Institutes of Health to P.W. (AI103807 and AI099625). G.C. is a Newton Advanced Fellow awarded by the Academy of Medical Sciences and the Newton Fund and a Janssen Investigator of Tsinghua University. Funding Information: This work was supported by grants from the National Natural Science Foundation of China to G.C. (81301412, 81422028, and 81571975), the National Key Basic Research Program of MOST to G.C. (2013CB911500), the Excellent Young Scientist Foundation of Beijing to G.C. (2013D009004000002), the Grand Challenges Explorations of the Bill and Melinda Gates Foundation to G.C. (OPP1021992), and the National Institutes of Health to P.W. (AI103807 and AI099625). G.C. is a Newton Advanced Fellow awarded by the Academy of Medical Sciences and the Newton Fund and a Janssen Investigator of Tsinghua University. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",
year = "2016",
month = mar,
day = "1",
doi = "10.1016/j.pt.2015.09.009",
language = "English (US)",
volume = "32",
pages = "177--186",
journal = "Trends in Parasitology",
issn = "1471-4922",
publisher = "Elsevier Limited",
number = "3",
}