TY - JOUR
T1 - Motile blood lymphocytes in B- and T-lymphocyte disorders. 1. Studies of chronic lymphocytic leukemia and X-linked hypogammaglobulinemia
AU - Goldman, Armond S.
AU - Schmalstieg, Frank C.
AU - Harris, Nick S.
AU - Rudloff, H. Beth
AU - Goldblum, Randall M.
AU - Alperin, Jack B.
N1 - Funding Information:
This work was supported in part by the National Institutes of Health Research Grant No. DHEW RR-00073-14, General Clinical Research Centers Branch; DHEW l-R01 CA l-5278-01; and DHEW 1 PO1 CA 16964-01.
PY - 1977/11
Y1 - 1977/11
N2 - The relative frequency of blood lymphocytes in a motile configuration was determined by interference contrast microscopy in adults with chronic lymphocytic leukemia (CLL), a B-cell malignancy, and in children with X-linked hypogammaglobulinemia, a genetic B-cell deficiency. The relative frequency of motile lymphocytes was sharply reduced in CLL, but remained normal or slightly increased in X-linked hypogamaglobulinemia. The number of motile lymphocytes in both diseases correlated with the number of circulating T cells as shown by E rosetting, but did not correlate with the number of B cells as determined by membrane-bound immunoglobulins. It appears, therefore, that lymphocyte motility is a functional morphological marker of T cells in certain immunologic diseases as well as in healthy individuals.
AB - The relative frequency of blood lymphocytes in a motile configuration was determined by interference contrast microscopy in adults with chronic lymphocytic leukemia (CLL), a B-cell malignancy, and in children with X-linked hypogammaglobulinemia, a genetic B-cell deficiency. The relative frequency of motile lymphocytes was sharply reduced in CLL, but remained normal or slightly increased in X-linked hypogamaglobulinemia. The number of motile lymphocytes in both diseases correlated with the number of circulating T cells as shown by E rosetting, but did not correlate with the number of B cells as determined by membrane-bound immunoglobulins. It appears, therefore, that lymphocyte motility is a functional morphological marker of T cells in certain immunologic diseases as well as in healthy individuals.
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U2 - 10.1016/0090-1229(77)90009-5
DO - 10.1016/0090-1229(77)90009-5
M3 - Article
C2 - 303159
AN - SCOPUS:0017747004
SN - 0090-1229
VL - 8
SP - 461
EP - 466
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 3
ER -