Motile blood lymphocytes in B- and T-lymphocyte disorders. 1. Studies of chronic lymphocytic leukemia and X-linked hypogammaglobulinemia

Armond S. Goldman, Frank C. Schmalstieg, Nick S. Harris, H. Beth Rudloff, Randall M. Goldblum, Jack B. Alperin

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The relative frequency of blood lymphocytes in a motile configuration was determined by interference contrast microscopy in adults with chronic lymphocytic leukemia (CLL), a B-cell malignancy, and in children with X-linked hypogammaglobulinemia, a genetic B-cell deficiency. The relative frequency of motile lymphocytes was sharply reduced in CLL, but remained normal or slightly increased in X-linked hypogamaglobulinemia. The number of motile lymphocytes in both diseases correlated with the number of circulating T cells as shown by E rosetting, but did not correlate with the number of B cells as determined by membrane-bound immunoglobulins. It appears, therefore, that lymphocyte motility is a functional morphological marker of T cells in certain immunologic diseases as well as in healthy individuals.

Original languageEnglish (US)
Pages (from-to)461-466
Number of pages6
JournalClinical Immunology and Immunopathology
Volume8
Issue number3
DOIs
StatePublished - Nov 1977

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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