Motile blood lymphocytes in B- and T-lymphocyte disorders. 1. Studies of chronic lymphocytic leukemia and X-linked hypogammaglobulinemia

Armond S. Goldman; Frank C. Schmalstieg; Nick S. Harris; H. Beth Rudloff; Randall M. Goldblum; Jack B. Alperin

doi:10.1016/0090-1229(77)90009-5

Motile blood lymphocytes in B- and T-lymphocyte disorders. 1. Studies of chronic lymphocytic leukemia and X-linked hypogammaglobulinemia

Armond S. Goldman, Frank C. Schmalstieg, Nick S. Harris, H. Beth Rudloff, Randall M. Goldblum, Jack B. Alperin

Research output: Contribution to journal › Article › peer-review

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Abstract

The relative frequency of blood lymphocytes in a motile configuration was determined by interference contrast microscopy in adults with chronic lymphocytic leukemia (CLL), a B-cell malignancy, and in children with X-linked hypogammaglobulinemia, a genetic B-cell deficiency. The relative frequency of motile lymphocytes was sharply reduced in CLL, but remained normal or slightly increased in X-linked hypogamaglobulinemia. The number of motile lymphocytes in both diseases correlated with the number of circulating T cells as shown by E rosetting, but did not correlate with the number of B cells as determined by membrane-bound immunoglobulins. It appears, therefore, that lymphocyte motility is a functional morphological marker of T cells in certain immunologic diseases as well as in healthy individuals.

Original language	English (US)
Pages (from-to)	461-466
Number of pages	6
Journal	Clinical Immunology and Immunopathology
Volume	8
Issue number	3
DOIs	https://doi.org/10.1016/0090-1229(77)90009-5
State	Published - Nov 1977
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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10.1016/0090-1229(77)90009-5

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title = "Motile blood lymphocytes in B- and T-lymphocyte disorders. 1. Studies of chronic lymphocytic leukemia and X-linked hypogammaglobulinemia",

abstract = "The relative frequency of blood lymphocytes in a motile configuration was determined by interference contrast microscopy in adults with chronic lymphocytic leukemia (CLL), a B-cell malignancy, and in children with X-linked hypogammaglobulinemia, a genetic B-cell deficiency. The relative frequency of motile lymphocytes was sharply reduced in CLL, but remained normal or slightly increased in X-linked hypogamaglobulinemia. The number of motile lymphocytes in both diseases correlated with the number of circulating T cells as shown by E rosetting, but did not correlate with the number of B cells as determined by membrane-bound immunoglobulins. It appears, therefore, that lymphocyte motility is a functional morphological marker of T cells in certain immunologic diseases as well as in healthy individuals.",

author = "Goldman, {Armond S.} and Schmalstieg, {Frank C.} and Harris, {Nick S.} and Rudloff, {H. Beth} and Goldblum, {Randall M.} and Alperin, {Jack B.}",

note = "Funding Information: This work was supported in part by the National Institutes of Health Research Grant No. DHEW RR-00073-14, General Clinical Research Centers Branch; DHEW l-R01 CA l-5278-01; and DHEW 1 PO1 CA 16964-01.",

year = "1977",

month = nov,

doi = "10.1016/0090-1229(77)90009-5",

language = "English (US)",

volume = "8",

pages = "461--466",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

number = "3",

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T1 - Motile blood lymphocytes in B- and T-lymphocyte disorders. 1. Studies of chronic lymphocytic leukemia and X-linked hypogammaglobulinemia

AU - Goldman, Armond S.

AU - Schmalstieg, Frank C.

AU - Harris, Nick S.

AU - Rudloff, H. Beth

AU - Goldblum, Randall M.

AU - Alperin, Jack B.

N1 - Funding Information: This work was supported in part by the National Institutes of Health Research Grant No. DHEW RR-00073-14, General Clinical Research Centers Branch; DHEW l-R01 CA l-5278-01; and DHEW 1 PO1 CA 16964-01.

PY - 1977/11

Y1 - 1977/11

N2 - The relative frequency of blood lymphocytes in a motile configuration was determined by interference contrast microscopy in adults with chronic lymphocytic leukemia (CLL), a B-cell malignancy, and in children with X-linked hypogammaglobulinemia, a genetic B-cell deficiency. The relative frequency of motile lymphocytes was sharply reduced in CLL, but remained normal or slightly increased in X-linked hypogamaglobulinemia. The number of motile lymphocytes in both diseases correlated with the number of circulating T cells as shown by E rosetting, but did not correlate with the number of B cells as determined by membrane-bound immunoglobulins. It appears, therefore, that lymphocyte motility is a functional morphological marker of T cells in certain immunologic diseases as well as in healthy individuals.

AB - The relative frequency of blood lymphocytes in a motile configuration was determined by interference contrast microscopy in adults with chronic lymphocytic leukemia (CLL), a B-cell malignancy, and in children with X-linked hypogammaglobulinemia, a genetic B-cell deficiency. The relative frequency of motile lymphocytes was sharply reduced in CLL, but remained normal or slightly increased in X-linked hypogamaglobulinemia. The number of motile lymphocytes in both diseases correlated with the number of circulating T cells as shown by E rosetting, but did not correlate with the number of B cells as determined by membrane-bound immunoglobulins. It appears, therefore, that lymphocyte motility is a functional morphological marker of T cells in certain immunologic diseases as well as in healthy individuals.

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Motile blood lymphocytes in B- and T-lymphocyte disorders. 1. Studies of chronic lymphocytic leukemia and X-linked hypogammaglobulinemia

Abstract

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