Abstract
The relative frequency of blood lymphocytes in a motile configuration was determined by interference contrast microscopy in adults with chronic lymphocytic leukemia (CLL), a B-cell malignancy, and in children with X-linked hypogammaglobulinemia, a genetic B-cell deficiency. The relative frequency of motile lymphocytes was sharply reduced in CLL, but remained normal or slightly increased in X-linked hypogamaglobulinemia. The number of motile lymphocytes in both diseases correlated with the number of circulating T cells as shown by E rosetting, but did not correlate with the number of B cells as determined by membrane-bound immunoglobulins. It appears, therefore, that lymphocyte motility is a functional morphological marker of T cells in certain immunologic diseases as well as in healthy individuals.
Original language | English (US) |
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Pages (from-to) | 461-466 |
Number of pages | 6 |
Journal | Clinical Immunology and Immunopathology |
Volume | 8 |
Issue number | 3 |
DOIs | |
State | Published - Nov 1977 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine
- Immunology