Motile blood lymphocytes in B- and T-lymphocyte disorders. 1. Studies of chronic lymphocytic leukemia and X-linked hypogammaglobulinemia

Armond S. Goldman, Frank C. Schmalstieg, Nick S. Harris, H. Beth Rudloff, Randall M. Goldblum, Jack B. Alperin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The relative frequency of blood lymphocytes in a motile configuration was determined by interference contrast microscopy in adults with chronic lymphocytic leukemia (CLL), a B-cell malignancy, and in children with X-linked hypogammaglobulinemia, a genetic B-cell deficiency. The relative frequency of motile lymphocytes was sharply reduced in CLL, but remained normal or slightly increased in X-linked hypogamaglobulinemia. The number of motile lymphocytes in both diseases correlated with the number of circulating T cells as shown by E rosetting, but did not correlate with the number of B cells as determined by membrane-bound immunoglobulins. It appears, therefore, that lymphocyte motility is a functional morphological marker of T cells in certain immunologic diseases as well as in healthy individuals.

Original languageEnglish (US)
Pages (from-to)461-466
Number of pages6
JournalClinical Immunology and Immunopathology
Volume8
Issue number3
DOIs
StatePublished - 1977

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B-Cell Chronic Lymphocytic Leukemia
Lymphocytes
T-Lymphocytes
B-Lymphocytes
Interference Microscopy
B-Cell Antigen Receptors
Immune System Diseases
Lymphocyte Count
X-Linked Hypogammaglobulinemia
Neoplasms

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Motile blood lymphocytes in B- and T-lymphocyte disorders. 1. Studies of chronic lymphocytic leukemia and X-linked hypogammaglobulinemia. / Goldman, Armond S.; Schmalstieg, Frank C.; Harris, Nick S.; Rudloff, H. Beth; Goldblum, Randall M.; Alperin, Jack B.

In: Clinical Immunology and Immunopathology, Vol. 8, No. 3, 1977, p. 461-466.

Research output: Contribution to journalArticle

Goldman, Armond S. ; Schmalstieg, Frank C. ; Harris, Nick S. ; Rudloff, H. Beth ; Goldblum, Randall M. ; Alperin, Jack B. / Motile blood lymphocytes in B- and T-lymphocyte disorders. 1. Studies of chronic lymphocytic leukemia and X-linked hypogammaglobulinemia. In: Clinical Immunology and Immunopathology. 1977 ; Vol. 8, No. 3. pp. 461-466.
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