Mouse muscle ε{lunate}- and γ-containing acetylcholine receptors expressed in Xenopus laevis oocytes do not differ in their degradation half-lives

Enchi Liu, Owen Hamill, Miriam M. Salpeter

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Mouse acetylcholine receptors (AChRs) consisting of either the embryonic form (2α, 1β, 1δ and 1γ) or the adult form (2α, 1β, 1δ and 1ε{lunate}) were expressed in Xenopus laevis oocytes. As expected, the single channel conductance was ∼52 pS and the exponential decay time constants were 2.2 and 8.2 ms for the γ-AChR and respectively 65 pS and 0.6 and 2.8 ms for the ε{lunate}-AChR. No difference was seen in the degradation rate between the γ- and ε{lunate}-containing AChRs, both having a half-life of about 5 days.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalNeuroscience Letters
Volume174
Issue number1
DOIs
StatePublished - Jun 6 1994
Externally publishedYes

Fingerprint

Xenopus laevis
Cholinergic Receptors
Oocytes
Muscles
Half-Life

Keywords

  • Acetylcholine receptor
  • Degradation
  • Epsilon subunit
  • mRNA
  • Oocyte
  • Patch clamp
  • αBungarotoxin
  • γ Subunit

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mouse muscle ε{lunate}- and γ-containing acetylcholine receptors expressed in Xenopus laevis oocytes do not differ in their degradation half-lives. / Liu, Enchi; Hamill, Owen; Salpeter, Miriam M.

In: Neuroscience Letters, Vol. 174, No. 1, 06.06.1994, p. 77-80.

Research output: Contribution to journalArticle

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