Mouse muscle ϵ- and γ-containing acetylcholine receptors expressed in Xenopus laevis oocytes do not differ in their degradation half-lives

Enchi Liu, Owen P. Hamill, Miriam M. Salpeter

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Mouse acetylcholine receptors (AChRs) consisting of either the embryonic form (2α, 1β, 1δ and 1γ) or the adult form (2α, 1β, 1δ and 1ε{lunate}) were expressed in Xenopus laevis oocytes. As expected, the single channel conductance was ∼52 pS and the exponential decay time constants were 2.2 and 8.2 ms for the γ-AChR and respectively 65 pS and 0.6 and 2.8 ms for the ε{lunate}-AChR. No difference was seen in the degradation rate between the γ- and ε{lunate}-containing AChRs, both having a half-life of about 5 days.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalNeuroscience Letters
Volume174
Issue number1
DOIs
StatePublished - Jun 6 1994
Externally publishedYes

Keywords

  • Acetylcholine receptor
  • Degradation
  • Epsilon subunit
  • Oocyte
  • Patch clamp
  • mRNA
  • αBungarotoxin
  • γ Subunit

ASJC Scopus subject areas

  • Neuroscience(all)

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