Mouse muscle ϵ- and γ-containing acetylcholine receptors expressed in Xenopus laevis oocytes do not differ in their degradation half-lives

Mouse acetylcholine receptors (AChRs) consisting of either the embryonic form (2α, 1β, 1δ and 1γ) or the adult form (2α, 1β, 1δ and 1ε{lunate}) were expressed in Xenopus laevis oocytes. As expected, the single channel conductance was ∼52 pS and the exponential decay time constants were 2.2 and 8.2 ms for the γ-AChR and respectively 65 pS and 0.6 and 2.8 ms for the ε{lunate}-AChR. No difference was seen in the degradation rate between the γ- and ε{lunate}-containing AChRs, both having a half-life of about 5 days.