Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype

David Beasley, Li Li, Miguel T. Suderman, Alan Barrett

Research output: Contribution to journalArticle

194 Citations (Scopus)

Abstract

Despite recent advances in the genetics of West Nile (WN) virus, relatively little is known about the molecular basis of virulence of this virus. In particular, although the genotype of the WN virus strain that was recently introduced into North America has been determined, there have been few experimental studies on the virulence phenotype of the virus. We compared genetic and neurovirulence properties of 19 strains of WN virus, including 2 from North America, and observed significant differences in their neuroinvasive phenotype in mice and hamsters that correlated with virus genotype. Virus isolated in North America was found to be highly neuroinvasive with a lack of age-related resistance to infection in mice normally associated with mosquito-borne flaviviruses.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalVirology
Volume296
Issue number1
DOIs
StatePublished - 2002

Fingerprint

West Nile virus
North America
Genotype
Viruses
Phenotype
Virulence
Flavivirus
Culicidae
Cricetinae
Infection

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype. / Beasley, David; Li, Li; Suderman, Miguel T.; Barrett, Alan.

In: Virology, Vol. 296, No. 1, 2002, p. 17-23.

Research output: Contribution to journalArticle

@article{218d26f0e93d45428a7b7c1ab3cd75ce,
title = "Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype",
abstract = "Despite recent advances in the genetics of West Nile (WN) virus, relatively little is known about the molecular basis of virulence of this virus. In particular, although the genotype of the WN virus strain that was recently introduced into North America has been determined, there have been few experimental studies on the virulence phenotype of the virus. We compared genetic and neurovirulence properties of 19 strains of WN virus, including 2 from North America, and observed significant differences in their neuroinvasive phenotype in mice and hamsters that correlated with virus genotype. Virus isolated in North America was found to be highly neuroinvasive with a lack of age-related resistance to infection in mice normally associated with mosquito-borne flaviviruses.",
author = "David Beasley and Li Li and Suderman, {Miguel T.} and Alan Barrett",
year = "2002",
doi = "10.1006/viro.2002.1372",
language = "English (US)",
volume = "296",
pages = "17--23",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype

AU - Beasley, David

AU - Li, Li

AU - Suderman, Miguel T.

AU - Barrett, Alan

PY - 2002

Y1 - 2002

N2 - Despite recent advances in the genetics of West Nile (WN) virus, relatively little is known about the molecular basis of virulence of this virus. In particular, although the genotype of the WN virus strain that was recently introduced into North America has been determined, there have been few experimental studies on the virulence phenotype of the virus. We compared genetic and neurovirulence properties of 19 strains of WN virus, including 2 from North America, and observed significant differences in their neuroinvasive phenotype in mice and hamsters that correlated with virus genotype. Virus isolated in North America was found to be highly neuroinvasive with a lack of age-related resistance to infection in mice normally associated with mosquito-borne flaviviruses.

AB - Despite recent advances in the genetics of West Nile (WN) virus, relatively little is known about the molecular basis of virulence of this virus. In particular, although the genotype of the WN virus strain that was recently introduced into North America has been determined, there have been few experimental studies on the virulence phenotype of the virus. We compared genetic and neurovirulence properties of 19 strains of WN virus, including 2 from North America, and observed significant differences in their neuroinvasive phenotype in mice and hamsters that correlated with virus genotype. Virus isolated in North America was found to be highly neuroinvasive with a lack of age-related resistance to infection in mice normally associated with mosquito-borne flaviviruses.

UR - http://www.scopus.com/inward/record.url?scp=0036343422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036343422&partnerID=8YFLogxK

U2 - 10.1006/viro.2002.1372

DO - 10.1006/viro.2002.1372

M3 - Article

C2 - 12036314

AN - SCOPUS:0036343422

VL - 296

SP - 17

EP - 23

JO - Virology

JF - Virology

SN - 0042-6822

IS - 1

ER -