Movement of myosin‐coated structures on actin cables

Michael P. Sheetz; James A. Spudich

doi:10.1002/cm.970030515

Movement of myosin‐coated structures on actin cables

Michael P. Sheetz, James A. Spudich

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Myosin‐coated spheres from 0.6 to 120 μm in diameter move in vitro on a substratum of polar arrays of actin cables derived from the alga Nitella. The force for this movement is provided by skeletal muscle myosin since it is ATP‐dependent, and N‐ethylmaleimide (NEM) inactivation of the myosin blocks movement. These observations demonstrate that attachment of myosin in a random orientation to structures will enable those structures to move along polar arrays of actin filaments.

Original language	English (US)
Pages (from-to)	485-489
Number of pages	5
Journal	Cell Motility
Volume	3
Issue number	5
DOIs	https://doi.org/10.1002/cm.970030515
State	Published - 1983
Externally published	Yes

Keywords

actin
cell motility
myosin
vesicle transport

ASJC Scopus subject areas

Cell Biology

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10.1002/cm.970030515

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abstract = "Myosin‐coated spheres from 0.6 to 120 μm in diameter move in vitro on a substratum of polar arrays of actin cables derived from the alga Nitella. The force for this movement is provided by skeletal muscle myosin since it is ATP‐dependent, and N‐ethylmaleimide (NEM) inactivation of the myosin blocks movement. These observations demonstrate that attachment of myosin in a random orientation to structures will enable those structures to move along polar arrays of actin filaments.",

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AU - Sheetz, Michael P.

AU - Spudich, James A.

PY - 1983

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AB - Myosin‐coated spheres from 0.6 to 120 μm in diameter move in vitro on a substratum of polar arrays of actin cables derived from the alga Nitella. The force for this movement is provided by skeletal muscle myosin since it is ATP‐dependent, and N‐ethylmaleimide (NEM) inactivation of the myosin blocks movement. These observations demonstrate that attachment of myosin in a random orientation to structures will enable those structures to move along polar arrays of actin filaments.

KW - actin

KW - cell motility

KW - myosin

KW - vesicle transport

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Movement of myosin‐coated structures on actin cables

Abstract

Keywords

ASJC Scopus subject areas

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