Movement of myosin‐coated structures on actin cables

Michael P. Sheetz, James A. Spudich

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Myosin‐coated spheres from 0.6 to 120 μm in diameter move in vitro on a substratum of polar arrays of actin cables derived from the alga Nitella. The force for this movement is provided by skeletal muscle myosin since it is ATP‐dependent, and N‐ethylmaleimide (NEM) inactivation of the myosin blocks movement. These observations demonstrate that attachment of myosin in a random orientation to structures will enable those structures to move along polar arrays of actin filaments.

Original languageEnglish (US)
Pages (from-to)485-489
Number of pages5
JournalCell Motility
Issue number5
StatePublished - 1983
Externally publishedYes


  • actin
  • cell motility
  • myosin
  • vesicle transport

ASJC Scopus subject areas

  • Cell Biology


Dive into the research topics of 'Movement of myosin‐coated structures on actin cables'. Together they form a unique fingerprint.

Cite this