MSCs in orthopedic surgery

Summer E. Hanson, Nicholas H. Maassen

Research output: Chapter in Book/Report/Conference proceedingChapter


Orthopedic injuries and pathology, both acute and chronic, result in debilitating problems afflicting millions of patients each year. Mainstays of treatment include physical therapy, inflammation and pain control, as well as surgical debridement, fixation, or replacement, depending on the disease process. Given the complex functional requirements of these musculoskeletal tissues, there is increasing interest in developing cell-based therapies for tissue regeneration rather than just replacement with scar, fibrosis, or alloplastic device. The case reports and series reviewed here offer unique and potentially superior approaches to ubiquitous and debilitating orthopedic diseases. Though in its infancy for regenerative applications such as those discussed here, cell-based therapy using mesenchymal stromal/stem cells (MSCs) could potentially affect the healing of musculoskeletal tissues.

Original languageEnglish (US)
Title of host publicationMesenchymal Stromal Cells
Subtitle of host publicationBiology and Clinical Applications
PublisherSpringer New York
Number of pages8
ISBN (Electronic)9781461457114
ISBN (Print)9781461457107
StatePublished - Jan 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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