Mucosal immunization of rhesus macaques with rift valley fever MP-12 vaccine

John C. Morrill, C. J. Peters

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Rhesus macaques given 5 × 104 or 1 × 105 plaque-forming units (pfu) of Rift Valley fever (RVF) MP-12 vaccine by oral, intranasal drops, or small particle aerosol showed no adverse effects up to 56 days after administration. All monkeys given the vaccine by aerosol or intranasal drops developed 80% plaque reduction neutralization titers of ≥ 1:40 by day 21 after inoculation. Only 2 of 4 monkeys given the vaccine by oral instillation developed detectable neutralizing antibodies. All monkeys vaccinated by mucosal routes that developed detectable neutralizing antibodies were protected against viremia when challenged with 1 × 105 pfu of virulent RVF virus delivered by a small particle aerosol at 56 days after vaccination. A single inoculation of the RVF MP-12 live attenuated vaccine by the aerosol or intranasal route may provide an alternative route of protective immunization to RVFV in addition to conventional intramuscular injection.

Original languageEnglish (US)
Pages (from-to)617-625
Number of pages9
JournalJournal of Infectious Diseases
Volume204
Issue number4
DOIs
StatePublished - Aug 15 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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