Multi-component extracellular matrices based on peptide self-assembly

Joel H. Collier, Jai S. Rudra, Joshua Z. Gasiorowski, Jangwook P. Jung

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

Extracellular matrices (ECMs) are challenging design targets for materials synthesis because they serve multiple biological roles, and they are composed of multiple molecular constituents. In addition, their composition and activities are dynamic and variable between tissues, and they are difficult to study mechanistically in physiological contexts. Nevertheless, the design of synthetic ECMs is a central consideration in applications such as regenerative medicine and 3D cell culture. In order to produce synthetic matrices having both multi-component construction and high levels of compositional definition, strategies based on molecular self-assembly are receiving increasing interest. These approaches are described in this tutorial review and compared with the structures and processes in native ECMs that serve as their inspiration.

Original languageEnglish (US)
Pages (from-to)3413-3424
Number of pages12
JournalChemical Society Reviews
Volume39
Issue number9
DOIs
StatePublished - Sep 2010
Externally publishedYes

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Self assembly
Peptides
Cell culture
Tissue
Chemical analysis
Regenerative Medicine

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Collier, J. H., Rudra, J. S., Gasiorowski, J. Z., & Jung, J. P. (2010). Multi-component extracellular matrices based on peptide self-assembly. Chemical Society Reviews, 39(9), 3413-3424. https://doi.org/10.1039/b914337h

Multi-component extracellular matrices based on peptide self-assembly. / Collier, Joel H.; Rudra, Jai S.; Gasiorowski, Joshua Z.; Jung, Jangwook P.

In: Chemical Society Reviews, Vol. 39, No. 9, 09.2010, p. 3413-3424.

Research output: Contribution to journalArticle

Collier, JH, Rudra, JS, Gasiorowski, JZ & Jung, JP 2010, 'Multi-component extracellular matrices based on peptide self-assembly', Chemical Society Reviews, vol. 39, no. 9, pp. 3413-3424. https://doi.org/10.1039/b914337h
Collier, Joel H. ; Rudra, Jai S. ; Gasiorowski, Joshua Z. ; Jung, Jangwook P. / Multi-component extracellular matrices based on peptide self-assembly. In: Chemical Society Reviews. 2010 ; Vol. 39, No. 9. pp. 3413-3424.
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