Multi-functional neuroprotective activity of neohesperidin dihydrochalcone: A novel scaffold for Alzheimer's disease therapeutics identified via drug repurposing screening

Keyphrases

• 8-anilino-1-naphthalenesulfonic Acid 9%
• Active Sites 9%
• Aggregation Behavior 9%
• Alzheimer's Disease 27%
• Alzheimer's Disease Treatment 100%
• Amyloid Aggregation Inhibition 9%
• Antioxidant 9%
• Antioxidant Activity 9%
• Atomic Force Microscopy 9%
• Cellular ROS 9%
• Co-incubation 18%
• Conformational Transition 9%
• Drug Repurposing 100%
• Dual-target Inhibitor 9%
• FDA-approved Drugs 9%
• Fibril Formation 9%
• In Vitro Bioassay 9%
• Inhibition Ability 9%
• Inhibitory Potency 9%
• Microscopic Study 9%
• Multi-target 9%
• Multitarget Drugs 9%
• Neohesperidin Dihydrochalcone 100%
• Neurological Disorders 9%
• Neuroprotective Activity 100%
• Neurotoxic Effects 9%
• Novel Scaffolds 100%
• Oligomeric 9%
• ROS Generation 9%
• Scavenging Activity 9%
• Signaling Cascades 9%
• State-resolved 9%
• Steady State 9%
• Steady Time 9%
• Substrate Recognition 9%
• Sweeteners 9%
• Thioflavin T 9%
• Time-resolved Fluorescence Spectroscopy 9%
• β-site APP-cleaving Enzyme 1 (BACE1) 27%

Pharmacology, Toxicology and Pharmaceutical Science

• 8-Anilinonaphthalene-1-Sulfonic Acid 9%
• Alzheimer's Disease 100%
• Amyloid Protein 9%
• Antioxidant 9%
• Antioxidant Capacity 9%
• Artificial Sweetener 9%
• Atomic Force Microscopy 9%
• Bioassay 9%
• Diseases 9%
• Drug Discovery 9%
• Drug Repositioning 100%
• Fluorescence Assay 9%
• Neohesperidin 100%
• Neurologic Disease 9%
• Neuroprotective Agent 100%
• Thioflavine 9%