Multi-peaked adaptive landscape for chikungunya virus evolution predicts continued fitness optimization in Aedes albopictus mosquitoes

Konstantin A. Tsetsarkin, Rubing Chen, Ruimei Yun, Shannan Rossi, Kenneth S. Plante, Mathilde Guerbois, Naomi Forrester, Guey Chuen Perng, Easwaran Sreekumar, Grace Leal, Jing Huang, Suchetana Mukhopadhyay, Scott Weaver

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Host species-specific fitness landscapes largely determine the outcome of host switching during pathogen emergence. Using chikungunya virus (CHIKV) to study adaptation to a mosquito vector, we evaluated mutations associated with recently evolved sub-lineages. Multiple Aedes albopictus-adaptive fitness peaks became available after CHIKV acquired an initial adaptive (E1-A226V) substitution, permitting rapid lineage diversification observed in nature. All second-step mutations involved replacements by glutamine or glutamic acid of E2 glycoprotein amino acids in the acid-sensitive region, providing a framework to anticipate additional A. albopictus-adaptive mutations. The combination of second-step adaptive mutations into a single, 'super-adaptive' fitness peak also predicted the future emergence of CHIKV strains with even greater transmission efficiency in some current regions of endemic circulation, followed by their likely global spread.

Original languageEnglish (US)
Article number4084
JournalNature Communications
Volume5
DOIs
StatePublished - Jun 16 2014

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Chikungunya virus
fitness
Aedes
viruses
mutations
Culicidae
Viruses
Mutation
optimization
Pathogens
glutamine
Glutamine
glutamic acid
transmission efficiency
acids
pathogens
Glutamic Acid
Glycoproteins
Substitution reactions
amino acids

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Multi-peaked adaptive landscape for chikungunya virus evolution predicts continued fitness optimization in Aedes albopictus mosquitoes. / Tsetsarkin, Konstantin A.; Chen, Rubing; Yun, Ruimei; Rossi, Shannan; Plante, Kenneth S.; Guerbois, Mathilde; Forrester, Naomi; Perng, Guey Chuen; Sreekumar, Easwaran; Leal, Grace; Huang, Jing; Mukhopadhyay, Suchetana; Weaver, Scott.

In: Nature Communications, Vol. 5, 4084, 16.06.2014.

Research output: Contribution to journalArticle

Tsetsarkin, KA, Chen, R, Yun, R, Rossi, S, Plante, KS, Guerbois, M, Forrester, N, Perng, GC, Sreekumar, E, Leal, G, Huang, J, Mukhopadhyay, S & Weaver, S 2014, 'Multi-peaked adaptive landscape for chikungunya virus evolution predicts continued fitness optimization in Aedes albopictus mosquitoes', Nature Communications, vol. 5, 4084. https://doi.org/10.1038/ncomms5084
Tsetsarkin, Konstantin A. ; Chen, Rubing ; Yun, Ruimei ; Rossi, Shannan ; Plante, Kenneth S. ; Guerbois, Mathilde ; Forrester, Naomi ; Perng, Guey Chuen ; Sreekumar, Easwaran ; Leal, Grace ; Huang, Jing ; Mukhopadhyay, Suchetana ; Weaver, Scott. / Multi-peaked adaptive landscape for chikungunya virus evolution predicts continued fitness optimization in Aedes albopictus mosquitoes. In: Nature Communications. 2014 ; Vol. 5.
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