Multicenter randomized trial of ofloxacin versus cefoxitin and doxycycline in outpatient treatment of pelvic inflammatory disease

M. G. Martens, S. Gordon, D. R. Yarborough, S. Faro, D. Binder, A. Berkeley, W. Ledger, S. Roy, W. Swartz, T. Madhavan, D. E. Soper, R. S G McNeeley, R. L. Sweet, D. S. Horner, P. L. Fulcher, W. J. McGanity, A. J. Friedman

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Abstract

    A multicenter randomized comparative trial was done to assess the safety and efficacy of oral ofloxacin (400 mg twice daily for 10 days) versus cefoxitin (2 g intramuscularly) followed by doxycycline (100 mg twice daily orally for 10 days) for the outpatient treatment of uncomplicated pelvic inflammatory disease (PID). Neisseria gonorrhoeae (GC) grew on pretreatment endocervical cultures from 43 of 268 women (16%), and in 30 of 247 women (12%) cultures were positive for Chlamydia trachomatis (Ct). Ninety-five percent (122/128) of the women treated with the ofloxacin regimen and 93% (112/121) of those treated with the cefoxitin/doxycycline regimen had cure or improvement on examination at a minimum of one follow-up visit. All GC species were eradicated by both ofloxacin and cefoxitin. Among women who returned for follow-up, the eradication of C trachomatis was 88% (15/17) for the cefoxitin/doxycycline group and 100% (18/18) for ofloxacin. Side effects were more prevalent in the cefoxitin/doxycycline group (15%) than in the ofloxacin group (7%), nausea/vomiting being the most frequent adverse effect. In this study, it appears that ofloxacin and cefoxitin/doxycycline have similar clinical effectiveness for the outpatient treatment of uncomplicated pelvic inflammatory disease.

    Original languageEnglish
    Pages (from-to)604-610
    Number of pages7
    JournalSouthern Medical Journal
    Volume86
    Issue number6
    StatePublished - 1993

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    Cefoxitin
    Pelvic Inflammatory Disease
    Ofloxacin
    Doxycycline
    Multicenter Studies
    Outpatients
    Therapeutics
    Neisseria gonorrhoeae
    Chlamydia trachomatis
    Nausea
    Vomiting
    Safety

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Martens, M. G., Gordon, S., Yarborough, D. R., Faro, S., Binder, D., Berkeley, A., ... Friedman, A. J. (1993). Multicenter randomized trial of ofloxacin versus cefoxitin and doxycycline in outpatient treatment of pelvic inflammatory disease. Southern Medical Journal, 86(6), 604-610.

    Multicenter randomized trial of ofloxacin versus cefoxitin and doxycycline in outpatient treatment of pelvic inflammatory disease. / Martens, M. G.; Gordon, S.; Yarborough, D. R.; Faro, S.; Binder, D.; Berkeley, A.; Ledger, W.; Roy, S.; Swartz, W.; Madhavan, T.; Soper, D. E.; McNeeley, R. S G; Sweet, R. L.; Horner, D. S.; Fulcher, P. L.; McGanity, W. J.; Friedman, A. J.

    In: Southern Medical Journal, Vol. 86, No. 6, 1993, p. 604-610.

    Research output: Contribution to journalArticle

    Martens, MG, Gordon, S, Yarborough, DR, Faro, S, Binder, D, Berkeley, A, Ledger, W, Roy, S, Swartz, W, Madhavan, T, Soper, DE, McNeeley, RSG, Sweet, RL, Horner, DS, Fulcher, PL, McGanity, WJ & Friedman, AJ 1993, 'Multicenter randomized trial of ofloxacin versus cefoxitin and doxycycline in outpatient treatment of pelvic inflammatory disease', Southern Medical Journal, vol. 86, no. 6, pp. 604-610.
    Martens, M. G. ; Gordon, S. ; Yarborough, D. R. ; Faro, S. ; Binder, D. ; Berkeley, A. ; Ledger, W. ; Roy, S. ; Swartz, W. ; Madhavan, T. ; Soper, D. E. ; McNeeley, R. S G ; Sweet, R. L. ; Horner, D. S. ; Fulcher, P. L. ; McGanity, W. J. ; Friedman, A. J. / Multicenter randomized trial of ofloxacin versus cefoxitin and doxycycline in outpatient treatment of pelvic inflammatory disease. In: Southern Medical Journal. 1993 ; Vol. 86, No. 6. pp. 604-610.
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    abstract = "A multicenter randomized comparative trial was done to assess the safety and efficacy of oral ofloxacin (400 mg twice daily for 10 days) versus cefoxitin (2 g intramuscularly) followed by doxycycline (100 mg twice daily orally for 10 days) for the outpatient treatment of uncomplicated pelvic inflammatory disease (PID). Neisseria gonorrhoeae (GC) grew on pretreatment endocervical cultures from 43 of 268 women (16{\%}), and in 30 of 247 women (12{\%}) cultures were positive for Chlamydia trachomatis (Ct). Ninety-five percent (122/128) of the women treated with the ofloxacin regimen and 93{\%} (112/121) of those treated with the cefoxitin/doxycycline regimen had cure or improvement on examination at a minimum of one follow-up visit. All GC species were eradicated by both ofloxacin and cefoxitin. Among women who returned for follow-up, the eradication of C trachomatis was 88{\%} (15/17) for the cefoxitin/doxycycline group and 100{\%} (18/18) for ofloxacin. Side effects were more prevalent in the cefoxitin/doxycycline group (15{\%}) than in the ofloxacin group (7{\%}), nausea/vomiting being the most frequent adverse effect. In this study, it appears that ofloxacin and cefoxitin/doxycycline have similar clinical effectiveness for the outpatient treatment of uncomplicated pelvic inflammatory disease.",
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    AU - Faro, S.

    AU - Binder, D.

    AU - Berkeley, A.

    AU - Ledger, W.

    AU - Roy, S.

    AU - Swartz, W.

    AU - Madhavan, T.

    AU - Soper, D. E.

    AU - McNeeley, R. S G

    AU - Sweet, R. L.

    AU - Horner, D. S.

    AU - Fulcher, P. L.

    AU - McGanity, W. J.

    AU - Friedman, A. J.

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