Multicentric meningioma evaluation with Tc-99m MIBI SPECT, CT, and MRI

F. Cesani, R. Ernst, G. Storey, Javier Villanueva-Meyer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Meningiomas comprise 15% of adult intracranial tumors. They are often found in middle-aged adults and are more likely to occur in women. They are frequently located in the lateral hemisphere convexity, the parasagittal region, and the falx cerebri. They originate from meningoendothelial cells within the arachnoid villi, but may arise from other meningeal constituents, such as fibroblasts and blood vessels. Multicentric meningiomas present at an earlier age, often associated with neurofibromatosis type 2. The authors report a case of a woman with multicentric meningiomas which were identified with Tc-99m MIBI SPECT, MRI, end CT. Tc-99m MIBI uptake is related to 1) tissue perfusion, and 2) normal call membrane and mitochondrial activity. In malignant tumors the uptake of Tc-99m MIBI also has been associated with the presence of P-glycoprotein in the cell membrane which is related to the multidrug resistant gene. The uptake of Tc-99m MIBI is not limited to malignant brain tumors, but also can be seen in benign end hypervascular meningiomas, as illustrated in this patient.

Original languageEnglish (US)
Pages (from-to)557-558
Number of pages2
JournalClinical Nuclear Medicine
Volume20
Issue number6
DOIs
StatePublished - 1995

Fingerprint

Technetium Tc 99m Sestamibi
Meningioma
Neurofibromatosis 2
Arachnoid
Mitochondrial Membranes
P-Glycoprotein
Single-Photon Emission-Computed Tomography
Brain Neoplasms
Blood Vessels
Neoplasms
Spinal Cord
Perfusion
Fibroblasts
Cell Membrane
Single Photon Emission Computed Tomography Computed Tomography
Genes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Multicentric meningioma evaluation with Tc-99m MIBI SPECT, CT, and MRI. / Cesani, F.; Ernst, R.; Storey, G.; Villanueva-Meyer, Javier.

In: Clinical Nuclear Medicine, Vol. 20, No. 6, 1995, p. 557-558.

Research output: Contribution to journalArticle

Cesani, F. ; Ernst, R. ; Storey, G. ; Villanueva-Meyer, Javier. / Multicentric meningioma evaluation with Tc-99m MIBI SPECT, CT, and MRI. In: Clinical Nuclear Medicine. 1995 ; Vol. 20, No. 6. pp. 557-558.
@article{73d153f480c2461d9526a267d69e0c21,
title = "Multicentric meningioma evaluation with Tc-99m MIBI SPECT, CT, and MRI",
abstract = "Meningiomas comprise 15{\%} of adult intracranial tumors. They are often found in middle-aged adults and are more likely to occur in women. They are frequently located in the lateral hemisphere convexity, the parasagittal region, and the falx cerebri. They originate from meningoendothelial cells within the arachnoid villi, but may arise from other meningeal constituents, such as fibroblasts and blood vessels. Multicentric meningiomas present at an earlier age, often associated with neurofibromatosis type 2. The authors report a case of a woman with multicentric meningiomas which were identified with Tc-99m MIBI SPECT, MRI, end CT. Tc-99m MIBI uptake is related to 1) tissue perfusion, and 2) normal call membrane and mitochondrial activity. In malignant tumors the uptake of Tc-99m MIBI also has been associated with the presence of P-glycoprotein in the cell membrane which is related to the multidrug resistant gene. The uptake of Tc-99m MIBI is not limited to malignant brain tumors, but also can be seen in benign end hypervascular meningiomas, as illustrated in this patient.",
author = "F. Cesani and R. Ernst and G. Storey and Javier Villanueva-Meyer",
year = "1995",
doi = "10.1097/00003072-199506000-00024",
language = "English (US)",
volume = "20",
pages = "557--558",
journal = "Clinical Nuclear Medicine",
issn = "0363-9762",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Multicentric meningioma evaluation with Tc-99m MIBI SPECT, CT, and MRI

AU - Cesani, F.

AU - Ernst, R.

AU - Storey, G.

AU - Villanueva-Meyer, Javier

PY - 1995

Y1 - 1995

N2 - Meningiomas comprise 15% of adult intracranial tumors. They are often found in middle-aged adults and are more likely to occur in women. They are frequently located in the lateral hemisphere convexity, the parasagittal region, and the falx cerebri. They originate from meningoendothelial cells within the arachnoid villi, but may arise from other meningeal constituents, such as fibroblasts and blood vessels. Multicentric meningiomas present at an earlier age, often associated with neurofibromatosis type 2. The authors report a case of a woman with multicentric meningiomas which were identified with Tc-99m MIBI SPECT, MRI, end CT. Tc-99m MIBI uptake is related to 1) tissue perfusion, and 2) normal call membrane and mitochondrial activity. In malignant tumors the uptake of Tc-99m MIBI also has been associated with the presence of P-glycoprotein in the cell membrane which is related to the multidrug resistant gene. The uptake of Tc-99m MIBI is not limited to malignant brain tumors, but also can be seen in benign end hypervascular meningiomas, as illustrated in this patient.

AB - Meningiomas comprise 15% of adult intracranial tumors. They are often found in middle-aged adults and are more likely to occur in women. They are frequently located in the lateral hemisphere convexity, the parasagittal region, and the falx cerebri. They originate from meningoendothelial cells within the arachnoid villi, but may arise from other meningeal constituents, such as fibroblasts and blood vessels. Multicentric meningiomas present at an earlier age, often associated with neurofibromatosis type 2. The authors report a case of a woman with multicentric meningiomas which were identified with Tc-99m MIBI SPECT, MRI, end CT. Tc-99m MIBI uptake is related to 1) tissue perfusion, and 2) normal call membrane and mitochondrial activity. In malignant tumors the uptake of Tc-99m MIBI also has been associated with the presence of P-glycoprotein in the cell membrane which is related to the multidrug resistant gene. The uptake of Tc-99m MIBI is not limited to malignant brain tumors, but also can be seen in benign end hypervascular meningiomas, as illustrated in this patient.

UR - http://www.scopus.com/inward/record.url?scp=0029002759&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029002759&partnerID=8YFLogxK

U2 - 10.1097/00003072-199506000-00024

DO - 10.1097/00003072-199506000-00024

M3 - Article

C2 - 7648749

AN - SCOPUS:0029002759

VL - 20

SP - 557

EP - 558

JO - Clinical Nuclear Medicine

JF - Clinical Nuclear Medicine

SN - 0363-9762

IS - 6

ER -