Multiple myeloma presented as acute interstitial nephritis and rheumatoid arthritis-like polyarthritis

Mohammad Reza Ardalan, Mohammadali Mohajel Shoja

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Acute interstitial nephritis and rheumatoid arthritis (RA) or RA-like polyarthritis are among the very rare paraneoplastic manifestations of multiple myeloma (MM). A 47-year-old man with acute renal failure due to interstitial nephritis was admitted to our university hospital and successfully treated with corticosteroid. He later developed a symmetric distal polyarthritis with morning stiffness mimicking RA. On follow-up, the patient had a rise in serum creatinine, hypercalcemia, anemia, and a monoclonal spike (Bence Jones protein) on the urine protein electrophoresis. Bone marrow biopsy demonstrated a diffuse neoplastic plasma cell infiltration. Diagnosis of MM was made and the patient received chemotherapy. After four-course chemotherapy, the patient's articular manifestations resolved, urine monoclonal spike disappeared, and serum creatinine returned to a near normal level. We hypothesize that in this case, immunologic hypersensitivity reactions to the light-chain molecules or other tumoral antigens deposited within the kidney or joint spaces, in the context of MM cytokine milieu may have resulted in this unusual presentation. Ultimately, clinicians and pathologists should consider MM in the differential diagnosis of the acute interstitial nephritis and RA-like polyarthritis.

Original languageEnglish (US)
Pages (from-to)309-313
Number of pages5
JournalAmerican Journal of Hematology
Volume82
Issue number4
DOIs
StatePublished - Apr 1 2007
Externally publishedYes

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Interstitial Nephritis
Multiple Myeloma
Arthritis
Rheumatoid Arthritis
Creatinine
Joints
Bence Jones Protein
Urine
Drug Therapy
Hypercalcemia
Plasma Cells
Serum
Acute Kidney Injury
Electrophoresis
Anemia
Adrenal Cortex Hormones
Hypersensitivity
Differential Diagnosis
Bone Marrow
Cytokines

Keywords

  • Arthritis
  • Interstitial nephritis
  • Multiple myeloma
  • Renal failure

ASJC Scopus subject areas

  • Hematology

Cite this

Multiple myeloma presented as acute interstitial nephritis and rheumatoid arthritis-like polyarthritis. / Ardalan, Mohammad Reza; Mohajel Shoja, Mohammadali.

In: American Journal of Hematology, Vol. 82, No. 4, 01.04.2007, p. 309-313.

Research output: Contribution to journalArticle

Ardalan, Mohammad Reza ; Mohajel Shoja, Mohammadali. / Multiple myeloma presented as acute interstitial nephritis and rheumatoid arthritis-like polyarthritis. In: American Journal of Hematology. 2007 ; Vol. 82, No. 4. pp. 309-313.
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