Multiscale biomechanical modeling of the human eye

Ioannis H. Karampelas, Edward P. Furlani, Anthony Nunez, Gianmarco Vizzeri

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A multiscale modeling approach is presented for advancing understanding of the biomechanical behavior of the human eye under various physiological conditions. The approach involves the development of large and small scale numerical models to predict stress and strain throughout the eye and its constituent anatomical structures that span length scales ranging from centimeters to microns. The numerical models are based on computational fluid dynamic (CFD) analysis combined with a fully-coupled fluid-structure interaction (FSI) capability as well finite element-based structural analysis. Preliminary modeling results of pressure-induced tissue deformation are demonstrated via application to an idealized eye geometry. A physical cadaveric eye model that will be used for model validation is also presented. A discussion is given of challenges and opportunities of using this approach to advance understanding of biomechanical behavior of the human eye.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Pages354-357
Number of pages4
StatePublished - Aug 9 2013
EventNanotechnology 2013: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 - Washington, DC, United States
Duration: May 12 2013May 16 2013

Publication series

NameTechnical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Volume2

Other

OtherNanotechnology 2013: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
CountryUnited States
CityWashington, DC
Period5/12/135/16/13

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Keywords

  • Eye biomechanics
  • ICP
  • IOP
  • Intracranial fluid structure interactions
  • Intracranial pressure
  • Intraocular pressure
  • ONSD
  • Optic nerve sheath diameter
  • Optic nerve stress
  • Stress and strain of eye tissue

ASJC Scopus subject areas

  • Biotechnology

Cite this

Karampelas, I. H., Furlani, E. P., Nunez, A., & Vizzeri, G. (2013). Multiscale biomechanical modeling of the human eye. In Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 (pp. 354-357). (Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013; Vol. 2).