Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida

Shelby R. Simar; Truc T. Tran; Kirsten B. Rydell; Diana Panesso; German A. Contreras; Jose M. Munita; Renzo O. Cifuentes; Lilian M. Abbo; Pranoti Sahasrabhojane; An Q. Dinh; Dierdre B. Axell-House; Tor Savidge; Samuel A. Shelburne; Blake M. Hanson; Cesar A. Arias

doi:10.1128/aac.01284-22

Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida

Shelby R. Simar
, Truc T. Tran
, Kirsten B. Rydell
, Diana Panesso
, German A. Contreras
, Jose M. Munita
, Renzo O. Cifuentes
, Lilian M. Abbo
, Pranoti Sahasrabhojane
, An Q. Dinh
, Dierdre B. Axell-House
, Tor Savidge
, Samuel A. Shelburne
, Blake M. Hanson
, Cesar A. Arias

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In the United States, vanB-mediated resistance in enterococci is rare. We characterized three sequence type (ST) 6, vancomycin-resistant Enterococcus faecalis isolates causing bacteremia in unique patients in spatiotemporally distinct settings. Isolates were recovered between 2018 and 2020 in two cities in the United States (Houston, TX; Miami, FL). The isolates harbored the vanB operon on a chromosomally located Tn1549 transposon, and epidemiological data suggested multiple introductions of the vanB gene cluster into ST6 E. faecalis.

Original language	English (US)
Journal	Antimicrobial agents and chemotherapy
Volume	67
Issue number	1
DOIs	https://doi.org/10.1128/aac.01284-22
State	Published - Jan 2023
Externally published	Yes

Keywords

Enterococcus
VRE
antimicrobial resistance

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/aac.01284-22

Cite this

Simar, S. R., Tran, T. T., Rydell, K. B., Panesso, D., Contreras, G. A., Munita, J. M., Cifuentes, R. O., Abbo, L. M., Sahasrabhojane, P., Dinh, A. Q., Axell-House, D. B., Savidge, T., Shelburne, S. A., Hanson, B. M., & Arias, C. A. (2023). Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida. Antimicrobial agents and chemotherapy, 67(1). https://doi.org/10.1128/aac.01284-22

Simar, SR, Tran, TT, Rydell, KB, Panesso, D, Contreras, GA, Munita, JM, Cifuentes, RO, Abbo, LM, Sahasrabhojane, P, Dinh, AQ, Axell-House, DB, Savidge, T, Shelburne, SA, Hanson, BM & Arias, CA 2023, 'Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida', Antimicrobial agents and chemotherapy, vol. 67, no. 1. https://doi.org/10.1128/aac.01284-22

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title = "Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida",

abstract = "In the United States, vanB-mediated resistance in enterococci is rare. We characterized three sequence type (ST) 6, vancomycin-resistant Enterococcus faecalis isolates causing bacteremia in unique patients in spatiotemporally distinct settings. Isolates were recovered between 2018 and 2020 in two cities in the United States (Houston, TX; Miami, FL). The isolates harbored the vanB operon on a chromosomally located Tn1549 transposon, and epidemiological data suggested multiple introductions of the vanB gene cluster into ST6 E. faecalis.",

keywords = "Enterococcus, VRE, antimicrobial resistance",

author = "Simar, \{Shelby R.\} and Tran, \{Truc T.\} and Rydell, \{Kirsten B.\} and Diana Panesso and Contreras, \{German A.\} and Munita, \{Jose M.\} and Cifuentes, \{Renzo O.\} and Abbo, \{Lilian M.\} and Pranoti Sahasrabhojane and Dinh, \{An Q.\} and Axell-House, \{Dierdre B.\} and Tor Savidge and Shelburne, \{Samuel A.\} and Hanson, \{Blake M.\} and Arias, \{Cesar A.\}",

year = "2023",

month = jan,

doi = "10.1128/aac.01284-22",

language = "English (US)",

volume = "67",

journal = "Antimicrobial agents and chemotherapy",

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AU - Simar, Shelby R.

AU - Tran, Truc T.

AU - Rydell, Kirsten B.

AU - Panesso, Diana

AU - Contreras, German A.

AU - Munita, Jose M.

AU - Cifuentes, Renzo O.

AU - Abbo, Lilian M.

AU - Sahasrabhojane, Pranoti

AU - Dinh, An Q.

AU - Axell-House, Dierdre B.

AU - Savidge, Tor

AU - Shelburne, Samuel A.

AU - Hanson, Blake M.

AU - Arias, Cesar A.

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N2 - In the United States, vanB-mediated resistance in enterococci is rare. We characterized three sequence type (ST) 6, vancomycin-resistant Enterococcus faecalis isolates causing bacteremia in unique patients in spatiotemporally distinct settings. Isolates were recovered between 2018 and 2020 in two cities in the United States (Houston, TX; Miami, FL). The isolates harbored the vanB operon on a chromosomally located Tn1549 transposon, and epidemiological data suggested multiple introductions of the vanB gene cluster into ST6 E. faecalis.

AB - In the United States, vanB-mediated resistance in enterococci is rare. We characterized three sequence type (ST) 6, vancomycin-resistant Enterococcus faecalis isolates causing bacteremia in unique patients in spatiotemporally distinct settings. Isolates were recovered between 2018 and 2020 in two cities in the United States (Houston, TX; Miami, FL). The isolates harbored the vanB operon on a chromosomally located Tn1549 transposon, and epidemiological data suggested multiple introductions of the vanB gene cluster into ST6 E. faecalis.

KW - Enterococcus

KW - VRE

KW - antimicrobial resistance

UR - https://www.scopus.com/pages/publications/85147047842

UR - https://www.scopus.com/pages/publications/85147047842#tab=citedBy

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AN - SCOPUS:85147047842

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JO - Antimicrobial agents and chemotherapy

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IS - 1

ER -

Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida

Abstract

Keywords

ASJC Scopus subject areas

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