Murine T-helper cell immune response to recombinant vaccinia-Venezuelan equine encephalitis virus

James H. Mathews; Richard M. Kinney; John T. Roehrig; Alan D.T. Barrett; Dennis W. Trent

doi:10.1016/0264-410X(94)90266-6

Murine T-helper cell immune response to recombinant vaccinia-Venezuelan equine encephalitis virus

James H. Mathews, Richard M. Kinney, John T. Roehrig, Alan D.T. Barrett, Dennis W. Trent

Pathology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The T-helper (Th) cell immune response following immunization of C3H (H-2^k) mice with a recombinant vaccinia (VAC) virus (TC-5A) expressing the structural proteins (capsid, E1 and E2) of the attenuated vaccine strain (TC-83) of Venezuelan equine encephalitis (VEE) virus was compared with the immune response induced in mice after immunization with TC-83 virus. TC-5A virus elicited Th cells that strongly recognized both VAC and TC-83 viruses in in vitro lymphoblastogenesis tests. Th-cell activation was associated with elevated levels of interleukin-2. TC-5A virus induced long-term humoral immunity; VEE virus-binding and neutralizing antibodies were detected in mouse sera collected from mice 16 months after a single immunization.

Original language	English (US)
Pages (from-to)	620-624
Number of pages	5
Journal	Vaccine
Volume	12
Issue number	7
DOIs	https://doi.org/10.1016/0264-410X(94)90266-6
State	Published - 1994

Keywords

Recombinant VAC-VEE virus
T-helper cell
immune response

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/0264-410X(94)90266-6

Cite this

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title = "Murine T-helper cell immune response to recombinant vaccinia-Venezuelan equine encephalitis virus",

abstract = "The T-helper (Th) cell immune response following immunization of C3H (H-2k) mice with a recombinant vaccinia (VAC) virus (TC-5A) expressing the structural proteins (capsid, E1 and E2) of the attenuated vaccine strain (TC-83) of Venezuelan equine encephalitis (VEE) virus was compared with the immune response induced in mice after immunization with TC-83 virus. TC-5A virus elicited Th cells that strongly recognized both VAC and TC-83 viruses in in vitro lymphoblastogenesis tests. Th-cell activation was associated with elevated levels of interleukin-2. TC-5A virus induced long-term humoral immunity; VEE virus-binding and neutralizing antibodies were detected in mouse sera collected from mice 16 months after a single immunization.",

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T1 - Murine T-helper cell immune response to recombinant vaccinia-Venezuelan equine encephalitis virus

AU - Mathews, James H.

AU - Kinney, Richard M.

AU - Roehrig, John T.

AU - Barrett, Alan D.T.

AU - Trent, Dennis W.

PY - 1994

Y1 - 1994

N2 - The T-helper (Th) cell immune response following immunization of C3H (H-2k) mice with a recombinant vaccinia (VAC) virus (TC-5A) expressing the structural proteins (capsid, E1 and E2) of the attenuated vaccine strain (TC-83) of Venezuelan equine encephalitis (VEE) virus was compared with the immune response induced in mice after immunization with TC-83 virus. TC-5A virus elicited Th cells that strongly recognized both VAC and TC-83 viruses in in vitro lymphoblastogenesis tests. Th-cell activation was associated with elevated levels of interleukin-2. TC-5A virus induced long-term humoral immunity; VEE virus-binding and neutralizing antibodies were detected in mouse sera collected from mice 16 months after a single immunization.

AB - The T-helper (Th) cell immune response following immunization of C3H (H-2k) mice with a recombinant vaccinia (VAC) virus (TC-5A) expressing the structural proteins (capsid, E1 and E2) of the attenuated vaccine strain (TC-83) of Venezuelan equine encephalitis (VEE) virus was compared with the immune response induced in mice after immunization with TC-83 virus. TC-5A virus elicited Th cells that strongly recognized both VAC and TC-83 viruses in in vitro lymphoblastogenesis tests. Th-cell activation was associated with elevated levels of interleukin-2. TC-5A virus induced long-term humoral immunity; VEE virus-binding and neutralizing antibodies were detected in mouse sera collected from mice 16 months after a single immunization.

KW - Recombinant VAC-VEE virus

KW - T-helper cell

KW - immune response

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Murine T-helper cell immune response to recombinant vaccinia-Venezuelan equine encephalitis virus

Abstract

Keywords

ASJC Scopus subject areas

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