Murine T-helper cell immune response to recombinant vaccinia-Venezuelan equine encephalitis virus

James H. Mathews, Richard M. Kinney, John T. Roehrig, Alan Barrett, Dennis W. Trent

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The T-helper (Th) cell immune response following immunization of C3H (H-2k) mice with a recombinant vaccinia (VAC) virus (TC-5A) expressing the structural proteins (capsid, E1 and E2) of the attenuated vaccine strain (TC-83) of Venezuelan equine encephalitis (VEE) virus was compared with the immune response induced in mice after immunization with TC-83 virus. TC-5A virus elicited Th cells that strongly recognized both VAC and TC-83 viruses in in vitro lymphoblastogenesis tests. Th-cell activation was associated with elevated levels of interleukin-2. TC-5A virus induced long-term humoral immunity; VEE virus-binding and neutralizing antibodies were detected in mouse sera collected from mice 16 months after a single immunization.

Original languageEnglish (US)
Pages (from-to)620-624
Number of pages5
JournalVaccine
Volume12
Issue number7
DOIs
StatePublished - 1994

Fingerprint

Venezuelan Equine Encephalitis Viruses
Venezuelan equine encephalitis virus
Vaccinia
Vaccinium
Helper-Inducer T-Lymphocytes
T-lymphocytes
immune response
Viruses
Immunization
viruses
immunization
mice
Virus Attachment
Attenuated Vaccines
Vaccinia virus
capsid
structural proteins
Capsid Proteins
live vaccines
Humoral Immunity

Keywords

  • immune response
  • Recombinant VAC-VEE virus
  • T-helper cell

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Murine T-helper cell immune response to recombinant vaccinia-Venezuelan equine encephalitis virus. / Mathews, James H.; Kinney, Richard M.; Roehrig, John T.; Barrett, Alan; Trent, Dennis W.

In: Vaccine, Vol. 12, No. 7, 1994, p. 620-624.

Research output: Contribution to journalArticle

Mathews, James H. ; Kinney, Richard M. ; Roehrig, John T. ; Barrett, Alan ; Trent, Dennis W. / Murine T-helper cell immune response to recombinant vaccinia-Venezuelan equine encephalitis virus. In: Vaccine. 1994 ; Vol. 12, No. 7. pp. 620-624.
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