Murine Typhus: A Life-Threatening Presentation of a Case in Galveston, Texas

Christopher Perez, Diaa Hamouda, Bernard Karnath

Research output: Contribution to journalArticle

Abstract

BACKGROUND Murine typhus is a rare bacterial infection caused by Rickettsia typhi, which is transmitted from rodents to humans through the infected Xenopsylla cheopis flea. The disease presentation is often non-specific, leading to unnecessary tests, and a delay in diagnosis and treatment. CASE REPORT A report is presented of a 22-year-old, previously healthy man, who presented with several symptoms and signs that increased in severity, requiring admission to the medical intensive care unit (MICU). After an extensive bacterial and viral laboratory workup, IgM and IgG titers confirmed the diagnosis of murine typhus due to infection by Rickettsia typhi. The patient was treated with doxycycline, which resulted in significant clinical improvement. CONCLUSIONS Murine typhus can present with a characteristic triad of fever, headache, and rash but also with other symptoms and signs and can vary in severity. Given its increasing prevalence in coastal cities, awareness of this infection and early diagnosis and treatment with doxycycline can reduce patient morbidity.

Original languageEnglish (US)
Pages (from-to)1503-1506
Number of pages4
JournalThe American journal of case reports
Volume19
DOIs
StatePublished - Dec 18 2018

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Endemic Flea-Borne Typhus
Rickettsia typhi
Doxycycline
Signs and Symptoms
Xenopsylla
Siphonaptera
Infection
Exanthema
Bacterial Infections
Immunoglobulin M
Headache
Intensive Care Units
Early Diagnosis
Rodentia
Fever
Immunoglobulin G
Morbidity
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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Murine Typhus : A Life-Threatening Presentation of a Case in Galveston, Texas. / Perez, Christopher; Hamouda, Diaa; Karnath, Bernard.

In: The American journal of case reports, Vol. 19, 18.12.2018, p. 1503-1506.

Research output: Contribution to journalArticle

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