Murine typhus

An important consideration for the nonspecific febrile illness

Gurjot Basra, Megan A. Berman, Lucas Blanton

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Murine typhus is a widely distributed flea-borne infection caused by Rickettsia typhi. Symptoms of murine typhus are nonspecific and mimic a variety of other infectious diseases. We herein report a case of murine typhus in an area where the broad use of DDT in the mid-20th century has now made it a rare disease. The patient described presented with headache, fever, and a faint macular rash. Initial laboratory studies revealed a slight transaminase elevation. Further questioning revealed exposure to opossums, prompting the consideration of murine typhus as a diagnosis. Although typhus group antibodies were not present during the patient's acute illness, empiric therapy with doxycycline was initiated, and the patient defervesced. One month after convalescence, the patient returned to clinic with serum that contained typhus group antibodies with an IgG titer of 1: 1024. Murine typhus is an important consideration during the workup of a patient with a nonspecific febrile illness. Exposure to reservoir hosts and the flea vector place humans at risk for this disease. Clinician recognition of this entity is required for diagnosis and effective therapy.

Original languageEnglish (US)
Article number134601
JournalCase Reports in Medicine
Volume2012
DOIs
StatePublished - 2012

Fingerprint

Endemic Flea-Borne Typhus
Fever
Epidemic Louse-Borne Typhus
Siphonaptera
Rickettsia typhi
Opossums
DDT
Antibodies
Doxycycline
Rare Diseases
Transaminases
Exanthema
Communicable Diseases
Headache
Immunoglobulin G
Therapeutics
Infection
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Murine typhus : An important consideration for the nonspecific febrile illness. / Basra, Gurjot; Berman, Megan A.; Blanton, Lucas.

In: Case Reports in Medicine, Vol. 2012, 134601, 2012.

Research output: Contribution to journalArticle

@article{6c9165c5db3443b88bee43b59661aff5,
title = "Murine typhus: An important consideration for the nonspecific febrile illness",
abstract = "Murine typhus is a widely distributed flea-borne infection caused by Rickettsia typhi. Symptoms of murine typhus are nonspecific and mimic a variety of other infectious diseases. We herein report a case of murine typhus in an area where the broad use of DDT in the mid-20th century has now made it a rare disease. The patient described presented with headache, fever, and a faint macular rash. Initial laboratory studies revealed a slight transaminase elevation. Further questioning revealed exposure to opossums, prompting the consideration of murine typhus as a diagnosis. Although typhus group antibodies were not present during the patient's acute illness, empiric therapy with doxycycline was initiated, and the patient defervesced. One month after convalescence, the patient returned to clinic with serum that contained typhus group antibodies with an IgG titer of 1: 1024. Murine typhus is an important consideration during the workup of a patient with a nonspecific febrile illness. Exposure to reservoir hosts and the flea vector place humans at risk for this disease. Clinician recognition of this entity is required for diagnosis and effective therapy.",
author = "Gurjot Basra and Berman, {Megan A.} and Lucas Blanton",
year = "2012",
doi = "10.1155/2012/134601",
language = "English (US)",
volume = "2012",
journal = "Case Reports in Medicine",
issn = "1687-9627",
publisher = "Hindawi Limited",

}

TY - JOUR

T1 - Murine typhus

T2 - An important consideration for the nonspecific febrile illness

AU - Basra, Gurjot

AU - Berman, Megan A.

AU - Blanton, Lucas

PY - 2012

Y1 - 2012

N2 - Murine typhus is a widely distributed flea-borne infection caused by Rickettsia typhi. Symptoms of murine typhus are nonspecific and mimic a variety of other infectious diseases. We herein report a case of murine typhus in an area where the broad use of DDT in the mid-20th century has now made it a rare disease. The patient described presented with headache, fever, and a faint macular rash. Initial laboratory studies revealed a slight transaminase elevation. Further questioning revealed exposure to opossums, prompting the consideration of murine typhus as a diagnosis. Although typhus group antibodies were not present during the patient's acute illness, empiric therapy with doxycycline was initiated, and the patient defervesced. One month after convalescence, the patient returned to clinic with serum that contained typhus group antibodies with an IgG titer of 1: 1024. Murine typhus is an important consideration during the workup of a patient with a nonspecific febrile illness. Exposure to reservoir hosts and the flea vector place humans at risk for this disease. Clinician recognition of this entity is required for diagnosis and effective therapy.

AB - Murine typhus is a widely distributed flea-borne infection caused by Rickettsia typhi. Symptoms of murine typhus are nonspecific and mimic a variety of other infectious diseases. We herein report a case of murine typhus in an area where the broad use of DDT in the mid-20th century has now made it a rare disease. The patient described presented with headache, fever, and a faint macular rash. Initial laboratory studies revealed a slight transaminase elevation. Further questioning revealed exposure to opossums, prompting the consideration of murine typhus as a diagnosis. Although typhus group antibodies were not present during the patient's acute illness, empiric therapy with doxycycline was initiated, and the patient defervesced. One month after convalescence, the patient returned to clinic with serum that contained typhus group antibodies with an IgG titer of 1: 1024. Murine typhus is an important consideration during the workup of a patient with a nonspecific febrile illness. Exposure to reservoir hosts and the flea vector place humans at risk for this disease. Clinician recognition of this entity is required for diagnosis and effective therapy.

UR - http://www.scopus.com/inward/record.url?scp=84923177547&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923177547&partnerID=8YFLogxK

U2 - 10.1155/2012/134601

DO - 10.1155/2012/134601

M3 - Article

VL - 2012

JO - Case Reports in Medicine

JF - Case Reports in Medicine

SN - 1687-9627

M1 - 134601

ER -