Muscle acetylcholine receptor loss in murine experimental autoimmune myasthenia gravis: Correlated with cellular, humoral and clinical responses

Premkumar Christadoss, Jon Lindstrom, Sam Munro, Norman Talal

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

An extensive analysis of the relationship between immunological parameters and clinical responses and biochemical loss of muscle acetylcholine receptors (AChR) was performed in murine experimental autoimmune myasthenia gravis. The onset of clinical muscle weakness correlated strongly with the onset of significant muscle AChR loss. Mice with clinical muscle weakness had greater amount of muscle AChR loss. There was no correlation between the concentration of anti-AChR antibodies and the presence of clinical muscle weakness or amount of muscle AChR loss. However, the kinetics of autoantibody response correlated well with that of muscle AChR loss.

Original languageEnglish (US)
Pages (from-to)29-41
Number of pages13
JournalJournal of Neuroimmunology
Volume8
Issue numberC
DOIs
StatePublished - 1985

Keywords

  • Anti-AChR antibodies
  • Murine experimental autoimmune myasthenia gravis
  • Muscle acetylcholine receptors (AChR)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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