Muscle acetylcholine receptor loss in murine experimental autoimmune myasthenia gravis

Correlated with cellular, humoral and clinical responses

Premkumar Christadoss, Jon Lindstrom, Sam Munro, Norman Talal

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

An extensive analysis of the relationship between immunological parameters and clinical responses and biochemical loss of muscle acetylcholine receptors (AChR) was performed in murine experimental autoimmune myasthenia gravis. The onset of clinical muscle weakness correlated strongly with the onset of significant muscle AChR loss. Mice with clinical muscle weakness had greater amount of muscle AChR loss. There was no correlation between the concentration of anti-AChR antibodies and the presence of clinical muscle weakness or amount of muscle AChR loss. However, the kinetics of autoantibody response correlated well with that of muscle AChR loss.

Original languageEnglish (US)
Pages (from-to)29-41
Number of pages13
JournalJournal of Neuroimmunology
Volume8
Issue numberC
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Autoimmune Experimental Myasthenia Gravis
Cholinergic Receptors
Muscles
Muscle Weakness
Autoantibodies
Antibodies

Keywords

  • Anti-AChR antibodies
  • Murine experimental autoimmune myasthenia gravis
  • Muscle acetylcholine receptors (AChR)

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

Muscle acetylcholine receptor loss in murine experimental autoimmune myasthenia gravis : Correlated with cellular, humoral and clinical responses. / Christadoss, Premkumar; Lindstrom, Jon; Munro, Sam; Talal, Norman.

In: Journal of Neuroimmunology, Vol. 8, No. C, 1985, p. 29-41.

Research output: Contribution to journalArticle

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