Muscle blood flow and distribution determine maximal V̇O2 of contracting muscle

W. N. Stainsby, W. F. Brechue, Bill Ameredes

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

During repetitive contractions, the V̇O2 of the dog gastrocnemius- plantaris muscle rose with the contraction frequency up to a maximal value and then decreased as contraction frequency was increased further. PVO2 was constant over most of the contraction frequency range. Reducing perfusion pressure/blood flow reduced V̇O(2max) with a constant PVO2. During these maneuvers the diffusion conductance, DCO2 (V̇O2/PVO2), changed with V̇O2. Raising the perfusion pressure/flow with a pump increased V̇O2 with a small rise in PVO2 so that DCO2 also increased. Removing tension from the muscle between contractions elevated V̇O2 and DCO2 without a change in perfusion pressure. Hypoxemia decreased V̇O2 with a decrease in PVO2; DCO2 remained constant. A three-compartment mathematical model, based on microsphere measurements of regional flow, was used to illustrate how regional flow variations may exist, and how they are poorly revealed in the mixed whole-muscle venous blood. The model shows V̇O2·g-1 strongly related to flow. As V̇O2·g-1 increased as ̇Q·g-1 increased, extraction decreased, and DCO2 increased.

Original languageEnglish (US)
Pages (from-to)43-46
Number of pages4
JournalMedicine and Science in Sports and Exercise
Volume27
Issue number1
StatePublished - 1995
Externally publishedYes

Fingerprint

Perfusion
Muscles
Skeletal Muscle
Pressure
Muscle Contraction
Microspheres
Theoretical Models
Dogs
Blood Pressure
Hypoxia

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Muscle blood flow and distribution determine maximal V̇O2 of contracting muscle. / Stainsby, W. N.; Brechue, W. F.; Ameredes, Bill.

In: Medicine and Science in Sports and Exercise, Vol. 27, No. 1, 1995, p. 43-46.

Research output: Contribution to journalArticle

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