Muscle metabolism, nutrition, and functional status in older adults

Douglas Paddon-Jones, Aaron P. Russell

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

In the last 50 years, the number of individuals over the age of 65 years in the United States has doubled. A further doubling is expected by 2030, dramatically increasing the number of adults at risk of sarcopenia, a condition characterized by an age-related loss of muscle mass with an associated reduction in physical function. A reduction in muscle mass and functional capacity is typically viewed as an undesirable, yet inevitable, consequence of aging, and in its early stages, may be easily masked by subtle lifestyle adaptations. However, advanced sarcopenia is synonymous with physical frailty and is associated with an increased likelihood of falls and impairments in the ability to perform routine activities of daily living. In many instances, the progression of sarcopenia is mirrored by a decrease in physical activity, which feeds into a vicious cycle of disuse and negative outcomes, including impaired insulin action, accelerated loss of muscle and bone mass, fatigue, impaired motor control and functional capacity, and increased morbidity and mortality.

Original languageEnglish (US)
Title of host publicationHandbook of Clinical Nutrition and Aging, Third Edition
PublisherSpringer New York
Pages113-124
Number of pages12
ISBN (Electronic)9781493919291
ISBN (Print)9781493919284
DOIs
StatePublished - Jan 1 2015

Keywords

  • Muscle mass
  • Nutrition
  • Protein metabolism
  • Sarcopenia
  • Strength and function

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Paddon-Jones, D., & Russell, A. P. (2015). Muscle metabolism, nutrition, and functional status in older adults. In Handbook of Clinical Nutrition and Aging, Third Edition (pp. 113-124). Springer New York. https://doi.org/10.1007/978-1-4939-1929-1_7