Muscle metabolism, nutrition, and functional status in older adults

Douglas Paddon-Jones, Aaron P. Russell

    Research output: Chapter in Book/Report/Conference proceedingChapter

    3 Scopus citations


    In the last 50 years, the number of individuals over the age of 65 years in the United States has doubled. A further doubling is expected by 2030, dramatically increasing the number of adults at risk of sarcopenia, a condition characterized by an age-related loss of muscle mass with an associated reduction in physical function. A reduction in muscle mass and functional capacity is typically viewed as an undesirable, yet inevitable, consequence of aging, and in its early stages, may be easily masked by subtle lifestyle adaptations. However, advanced sarcopenia is synonymous with physical frailty and is associated with an increased likelihood of falls and impairments in the ability to perform routine activities of daily living. In many instances, the progression of sarcopenia is mirrored by a decrease in physical activity, which feeds into a vicious cycle of disuse and negative outcomes, including impaired insulin action, accelerated loss of muscle and bone mass, fatigue, impaired motor control and functional capacity, and increased morbidity and mortality.

    Original languageEnglish (US)
    Title of host publicationHandbook of Clinical Nutrition and Aging, Third Edition
    PublisherSpringer New York
    Number of pages12
    ISBN (Electronic)9781493919291
    ISBN (Print)9781493919284
    StatePublished - Jan 1 2015


    • Muscle mass
    • Nutrition
    • Protein metabolism
    • Sarcopenia
    • Strength and function

    ASJC Scopus subject areas

    • General Medicine
    • General Biochemistry, Genetics and Molecular Biology


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