Muscle protein turnover following resistance exercise

S. M. Phillips, K. D. Tipton, A. A. Aarsland, Steven Wolf, R. R. Wolfe

Research output: Contribution to journalArticle

Abstract

The fractional synthetic rate (FSR) and fractional breakdown rate (FBR) of mixed skeletal muscle protein were determined, using primed constant infusions of d5-phenylalanine and 15N-phenylalanine respectively, prior to and following an isolated bout of resistance exercise. Subjects were 8 healthy volunteers (4 male, 4 female, age=21± lyr; mean±SE) who were studied at: rest, and at 3h, 24h, and 48h post-exercise, in the fasted condition. Exercise resulted in a 112% increase in FSR, above rest (P<0.05), at 3h post-exercise. In addition, FSR remained elevated by 65% and 34% at 24h and 48h, respectively (P<0.05). Exercise also resulted in elevations in FBR: 3h=31%, and 24h=18% (P<0.05). However, FBR was at resting levels by 48h Net muscle protein balance (FSR - FBR) was higher than rest at all times studied, but was highest at 3h post-exercise (rest=-0.0573±0.003; 3h=-0.0298±0.003; 24h=-0.0413±0.004; 48h=-0.0440±0.005; all %/h; P<0.01) Muscle protein net balance was always significantly less than zero, however. There was also a significant correlation between FSR and FBR (r=0.88; P<0.001). These results indicate that a single bout of weightlifting results in a stimulation of both FSR and FBR, but that FSR remains elevated for longer than FBR These results clearly demonstrate that exercise results in an increased protein balance within muscle, up to 48h post-exercise.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - Dec 1 1997

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strength training
Muscle Proteins
muscle protein
protein metabolism
exercise
Exercise
Phenylalanine
Muscle
phenylalanine
Proteins
volunteers
skeletal muscle
Healthy Volunteers
Skeletal Muscle
muscles
Muscles

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Phillips, S. M., Tipton, K. D., Aarsland, A. A., Wolf, S., & Wolfe, R. R. (1997). Muscle protein turnover following resistance exercise. FASEB Journal, 11(3).

Muscle protein turnover following resistance exercise. / Phillips, S. M.; Tipton, K. D.; Aarsland, A. A.; Wolf, Steven; Wolfe, R. R.

In: FASEB Journal, Vol. 11, No. 3, 01.12.1997.

Research output: Contribution to journalArticle

Phillips, SM, Tipton, KD, Aarsland, AA, Wolf, S & Wolfe, RR 1997, 'Muscle protein turnover following resistance exercise', FASEB Journal, vol. 11, no. 3.
Phillips SM, Tipton KD, Aarsland AA, Wolf S, Wolfe RR. Muscle protein turnover following resistance exercise. FASEB Journal. 1997 Dec 1;11(3).
Phillips, S. M. ; Tipton, K. D. ; Aarsland, A. A. ; Wolf, Steven ; Wolfe, R. R. / Muscle protein turnover following resistance exercise. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
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