Muscle tissue changes with aging

Elena Volpi, Reza Nazemi, Satoshi Fujita

Research output: Contribution to journalReview article

141 Scopus citations

Abstract

Purpose of review: This review article focuses on the changes that occur in muscle with age, specifically the involuntary loss of muscle mass, strength and function, termed sarcopenia. Particular emphasis is given to the metabolic alterations that characterize sarcopenia, and to the potentially treatable causes of this condition, including age-related endocrine and nutritional changes, and inactivity. Recent findings: Recent data reported include those regarding the potential role of insulin resistance in the development of sarcopenia, the potential role of androgens and growth hormone in the treatment of this condition, the usefulness of exercise including both resistance and aerobic training to improve muscle growth and function, and, finally, the possible use of nutritional manipulations to improve muscle mass. Summary: Sarcopenia is likely a multifactorial condition that impairs physical function and predisposes to disability. It may be prevented or treated with lifestyle interventions and pharmacological treatment. Further long-term investigations are needed, however, to ascertain what type and combinations of interventions are the most efficacious in improving muscle mass and function in older people.

Original languageEnglish (US)
Pages (from-to)405-410
Number of pages6
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Volume7
Issue number4
DOIs
StatePublished - Jul 1 2004
Externally publishedYes

Keywords

  • Aging
  • Exercise
  • Hormones
  • Metabolism
  • Muscle
  • Nutrition
  • Sarcopenia

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Muscle tissue changes with aging'. Together they form a unique fingerprint.

  • Cite this