Abstract
Purpose of review: This review article focuses on the changes that occur in muscle with age, specifically the involuntary loss of muscle mass, strength and function, termed sarcopenia. Particular emphasis is given to the metabolic alterations that characterize sarcopenia, and to the potentially treatable causes of this condition, including age-related endocrine and nutritional changes, and inactivity. Recent findings: Recent data reported include those regarding the potential role of insulin resistance in the development of sarcopenia, the potential role of androgens and growth hormone in the treatment of this condition, the usefulness of exercise including both resistance and aerobic training to improve muscle growth and function, and, finally, the possible use of nutritional manipulations to improve muscle mass. Summary: Sarcopenia is likely a multifactorial condition that impairs physical function and predisposes to disability. It may be prevented or treated with lifestyle interventions and pharmacological treatment. Further long-term investigations are needed, however, to ascertain what type and combinations of interventions are the most efficacious in improving muscle mass and function in older people.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 405-410 |
| Number of pages | 6 |
| Journal | Current Opinion in Clinical Nutrition and Metabolic Care |
| Volume | 7 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2004 |
| Externally published | Yes |
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Keywords
- Aging
- Exercise
- Hormones
- Metabolism
- Muscle
- Nutrition
- Sarcopenia
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Endocrinology
- Food Science
- Endocrinology, Diabetes and Metabolism
Cite this
Muscle tissue changes with aging. / Volpi, Elena; Nazemi, Reza; Fujita, Satoshi.
In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 7, No. 4, 07.2004, p. 405-410.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Muscle tissue changes with aging
AU - Volpi, Elena
AU - Nazemi, Reza
AU - Fujita, Satoshi
PY - 2004/7
Y1 - 2004/7
N2 - Purpose of review: This review article focuses on the changes that occur in muscle with age, specifically the involuntary loss of muscle mass, strength and function, termed sarcopenia. Particular emphasis is given to the metabolic alterations that characterize sarcopenia, and to the potentially treatable causes of this condition, including age-related endocrine and nutritional changes, and inactivity. Recent findings: Recent data reported include those regarding the potential role of insulin resistance in the development of sarcopenia, the potential role of androgens and growth hormone in the treatment of this condition, the usefulness of exercise including both resistance and aerobic training to improve muscle growth and function, and, finally, the possible use of nutritional manipulations to improve muscle mass. Summary: Sarcopenia is likely a multifactorial condition that impairs physical function and predisposes to disability. It may be prevented or treated with lifestyle interventions and pharmacological treatment. Further long-term investigations are needed, however, to ascertain what type and combinations of interventions are the most efficacious in improving muscle mass and function in older people.
AB - Purpose of review: This review article focuses on the changes that occur in muscle with age, specifically the involuntary loss of muscle mass, strength and function, termed sarcopenia. Particular emphasis is given to the metabolic alterations that characterize sarcopenia, and to the potentially treatable causes of this condition, including age-related endocrine and nutritional changes, and inactivity. Recent findings: Recent data reported include those regarding the potential role of insulin resistance in the development of sarcopenia, the potential role of androgens and growth hormone in the treatment of this condition, the usefulness of exercise including both resistance and aerobic training to improve muscle growth and function, and, finally, the possible use of nutritional manipulations to improve muscle mass. Summary: Sarcopenia is likely a multifactorial condition that impairs physical function and predisposes to disability. It may be prevented or treated with lifestyle interventions and pharmacological treatment. Further long-term investigations are needed, however, to ascertain what type and combinations of interventions are the most efficacious in improving muscle mass and function in older people.
KW - Aging
KW - Exercise
KW - Hormones
KW - Metabolism
KW - Muscle
KW - Nutrition
KW - Sarcopenia
UR - http://www.scopus.com/inward/record.url?scp=10344262781&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10344262781&partnerID=8YFLogxK
U2 - 10.1097/01.mco.0000134362.76653.b2
DO - 10.1097/01.mco.0000134362.76653.b2
M3 - Article
C2 - 15192443
AN - SCOPUS:10344262781
VL - 7
SP - 405
EP - 410
JO - Current Opinion in Clinical Nutrition and Metabolic Care
JF - Current Opinion in Clinical Nutrition and Metabolic Care
SN - 1363-1950
IS - 4
ER -