Muscle Weakness Is Associated With Diabetes in Older Mexicans

The Mexican Health and Aging Study

Mark D. Peterson, Ryan McGrath, Peng Zhang, Kyriakos Markides, Soham Al Snih al snih, Rebeca Wong

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: The risk of cardiovascular problems due to diabetes mellitus is highest among older Mexicans, and yet what remains to be determined is the association between muscle weakness and diabetes in this population. Therefore, the purpose of this study was to determine the association between muscle strength and diabetes among Mexican adults greater than 50 years of age. Design: Cross-sectional. Setting: National sample of households in both urban and rural areas. Participants: A subsample of 1841 individuals aged 50 years and older was included from the 2012 Mexican Health and Aging Study. Measurements: Strength was assessed using a hand-held dynamometer, and the single largest reading from either hand was normalized to body mass (normalized grip strength [NGS]). Conditional inference tree analyses were used to identify sex-specific NGS weakness thresholds. Linear regression was used to examine the association between NGS and HbA1c, and logistic regression was used to assess the association between weakness and risk of diabetes (HbA1c ≥ 6.5% [≥48 mmol/mol]), after controlling for age, sex, and waist circumference. Results: NGS was inversely associated with HbA1c (β = -1.56; . P <.001). Optimal sex-specific NGS weakness thresholds to detect diabetes were ≤0.46 and ≤0.30 for men and women, respectively. Weakness was associated with significantly increased odds of diabetes (odds ratio, 1.69; 95% confidence interval, 1.37-2.10), even after adjusting for age, sex, and waist circumference. Conclusions: NGS was robustly associated with diabetes and other cardiometabolic risk factors in older Mexicans. This simple screen may serve as a valuable tool to identify adults that are at risk for negative health consequences or early mortality and who might benefit from lifestyle interventions to reduce risk.

Original languageEnglish (US)
JournalJournal of the American Medical Directors Association
DOIs
StateAccepted/In press - 2016

Fingerprint

Muscle Weakness
Hand Strength
Health
Waist Circumference
Hand
Muscle Strength
Life Style
Reading
Linear Models
Diabetes Mellitus
Logistic Models
Odds Ratio
Confidence Intervals
Mortality
Population

Keywords

  • Aging
  • Diabetes
  • Epidemiology
  • Insulin resistance
  • Muscle weakness

ASJC Scopus subject areas

  • Medicine(all)
  • Nursing(all)
  • Health Policy

Cite this

@article{00735e8680764dcda0d78f2828558eff,
title = "Muscle Weakness Is Associated With Diabetes in Older Mexicans: The Mexican Health and Aging Study",
abstract = "Background: The risk of cardiovascular problems due to diabetes mellitus is highest among older Mexicans, and yet what remains to be determined is the association between muscle weakness and diabetes in this population. Therefore, the purpose of this study was to determine the association between muscle strength and diabetes among Mexican adults greater than 50 years of age. Design: Cross-sectional. Setting: National sample of households in both urban and rural areas. Participants: A subsample of 1841 individuals aged 50 years and older was included from the 2012 Mexican Health and Aging Study. Measurements: Strength was assessed using a hand-held dynamometer, and the single largest reading from either hand was normalized to body mass (normalized grip strength [NGS]). Conditional inference tree analyses were used to identify sex-specific NGS weakness thresholds. Linear regression was used to examine the association between NGS and HbA1c, and logistic regression was used to assess the association between weakness and risk of diabetes (HbA1c ≥ 6.5{\%} [≥48 mmol/mol]), after controlling for age, sex, and waist circumference. Results: NGS was inversely associated with HbA1c (β = -1.56; . P <.001). Optimal sex-specific NGS weakness thresholds to detect diabetes were ≤0.46 and ≤0.30 for men and women, respectively. Weakness was associated with significantly increased odds of diabetes (odds ratio, 1.69; 95{\%} confidence interval, 1.37-2.10), even after adjusting for age, sex, and waist circumference. Conclusions: NGS was robustly associated with diabetes and other cardiometabolic risk factors in older Mexicans. This simple screen may serve as a valuable tool to identify adults that are at risk for negative health consequences or early mortality and who might benefit from lifestyle interventions to reduce risk.",
keywords = "Aging, Diabetes, Epidemiology, Insulin resistance, Muscle weakness",
author = "Peterson, {Mark D.} and Ryan McGrath and Peng Zhang and Kyriakos Markides and {Al Snih al snih}, Soham and Rebeca Wong",
year = "2016",
doi = "10.1016/j.jamda.2016.06.007",
language = "English (US)",
journal = "Journal of the American Medical Directors Association",
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TY - JOUR

T1 - Muscle Weakness Is Associated With Diabetes in Older Mexicans

T2 - The Mexican Health and Aging Study

AU - Peterson, Mark D.

AU - McGrath, Ryan

AU - Zhang, Peng

AU - Markides, Kyriakos

AU - Al Snih al snih, Soham

AU - Wong, Rebeca

PY - 2016

Y1 - 2016

N2 - Background: The risk of cardiovascular problems due to diabetes mellitus is highest among older Mexicans, and yet what remains to be determined is the association between muscle weakness and diabetes in this population. Therefore, the purpose of this study was to determine the association between muscle strength and diabetes among Mexican adults greater than 50 years of age. Design: Cross-sectional. Setting: National sample of households in both urban and rural areas. Participants: A subsample of 1841 individuals aged 50 years and older was included from the 2012 Mexican Health and Aging Study. Measurements: Strength was assessed using a hand-held dynamometer, and the single largest reading from either hand was normalized to body mass (normalized grip strength [NGS]). Conditional inference tree analyses were used to identify sex-specific NGS weakness thresholds. Linear regression was used to examine the association between NGS and HbA1c, and logistic regression was used to assess the association between weakness and risk of diabetes (HbA1c ≥ 6.5% [≥48 mmol/mol]), after controlling for age, sex, and waist circumference. Results: NGS was inversely associated with HbA1c (β = -1.56; . P <.001). Optimal sex-specific NGS weakness thresholds to detect diabetes were ≤0.46 and ≤0.30 for men and women, respectively. Weakness was associated with significantly increased odds of diabetes (odds ratio, 1.69; 95% confidence interval, 1.37-2.10), even after adjusting for age, sex, and waist circumference. Conclusions: NGS was robustly associated with diabetes and other cardiometabolic risk factors in older Mexicans. This simple screen may serve as a valuable tool to identify adults that are at risk for negative health consequences or early mortality and who might benefit from lifestyle interventions to reduce risk.

AB - Background: The risk of cardiovascular problems due to diabetes mellitus is highest among older Mexicans, and yet what remains to be determined is the association between muscle weakness and diabetes in this population. Therefore, the purpose of this study was to determine the association between muscle strength and diabetes among Mexican adults greater than 50 years of age. Design: Cross-sectional. Setting: National sample of households in both urban and rural areas. Participants: A subsample of 1841 individuals aged 50 years and older was included from the 2012 Mexican Health and Aging Study. Measurements: Strength was assessed using a hand-held dynamometer, and the single largest reading from either hand was normalized to body mass (normalized grip strength [NGS]). Conditional inference tree analyses were used to identify sex-specific NGS weakness thresholds. Linear regression was used to examine the association between NGS and HbA1c, and logistic regression was used to assess the association between weakness and risk of diabetes (HbA1c ≥ 6.5% [≥48 mmol/mol]), after controlling for age, sex, and waist circumference. Results: NGS was inversely associated with HbA1c (β = -1.56; . P <.001). Optimal sex-specific NGS weakness thresholds to detect diabetes were ≤0.46 and ≤0.30 for men and women, respectively. Weakness was associated with significantly increased odds of diabetes (odds ratio, 1.69; 95% confidence interval, 1.37-2.10), even after adjusting for age, sex, and waist circumference. Conclusions: NGS was robustly associated with diabetes and other cardiometabolic risk factors in older Mexicans. This simple screen may serve as a valuable tool to identify adults that are at risk for negative health consequences or early mortality and who might benefit from lifestyle interventions to reduce risk.

KW - Aging

KW - Diabetes

KW - Epidemiology

KW - Insulin resistance

KW - Muscle weakness

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