Mutagenic cholesterol preparations

Leland L. Smith, Vera B. Smart, Ghulam Ansari

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Naturally air-aged commercial samples of USP or reagent-grade cholesterol contain components which are mutagenic towards Salmonella typhimurium strains TA1537, TA1538 and TA98. These mutagenic components are associated with the polar cholesterol autoxidation products, but identify of the mutagenic components has not been achieved. Pure crystalline nonmutagenic cholesterol free from autoxidation products becomes mutagenic towards these strains upon heating at 70° in air or following exposure to 60Co γ-radiation.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalMutation Research/Genetic Toxicology
Volume68
Issue number1
DOIs
StatePublished - 1979

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Cholesterol
Air
Salmonella
Salmonella typhimurium
Heating
Radiation
Crystalline materials

ASJC Scopus subject areas

  • Genetics
  • Toxicology
  • Medicine(all)

Cite this

Mutagenic cholesterol preparations. / Smith, Leland L.; Smart, Vera B.; Ansari, Ghulam.

In: Mutation Research/Genetic Toxicology, Vol. 68, No. 1, 1979, p. 23-30.

Research output: Contribution to journalArticle

Smith, Leland L. ; Smart, Vera B. ; Ansari, Ghulam. / Mutagenic cholesterol preparations. In: Mutation Research/Genetic Toxicology. 1979 ; Vol. 68, No. 1. pp. 23-30.
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