Myasthenia gravis: A review

Annapurni Jayam Trouth, Alok Dabi, Noha Solieman, Mohankumar Kurukumbi, Janaki Kalyanam

Research output: Contribution to journalReview article

56 Scopus citations

Abstract

Acquired myasthenia gravis is a relatively uncommon disorder, with prevalence rates that have increased to about 20 per 100,000 in the US population. This autoimmune disease is characterized by muscle weakness that fluctuates, worsening with exertion, and improving with rest. In about two-thirds of the patients, the involvement of extrinsic ocular muscle presents as the initial symptom, usually progressing to involve other bulbar muscles and limb musculature, resulting in generalized myasthenia gravis. Although the cause of the disorder is unknown, the role of circulating antibodies directed against the nicotinic acetylcholine receptor in its pathogenesis is well established. As this disorder is highly treatable, prompt recognition is crucial. During the past decade, significant progress has been made in our understanding of the disease, leading to new treatment modalities and a significant reduction in morbidity and mortality.

Original languageEnglish (US)
Article number874680
JournalAutoimmune Diseases
Volume1
Issue number1
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Immunology and Microbiology (miscellaneous)

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